Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis

Satoshi Matsuzaki, Sachiko Matsuzaki, Michel Canis, Rei Yokomizo, Ryo Yokomizo, Nobuo Yaegashi, M Bruhat, Maurice A Bruhat, K. Okamura, Kunihiro Okamura
Human Reproduction · 2003 · vol. 18(1) , pp. 152–166 · doi:10.1093/humrep/deg007 · PMID:12525458 · W2143356576
article OA: bronze CC0 ⤵ 5 in-corpus citations
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Erythropoietin and its receptor are present in peritoneal endometriosis and eutopic endometrium, with differential expression in lesion subtypes, suggesting a role in endometriosis pathophysiology.

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Abstract

BACKGROUND: Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease. Therefore, we hypothesized that Epo may play a role in the pathogenesis of endometriosis, particularly during the early stages of the disease. METHOD: We investigated the localization of Epo and the Epo receptor (Epo-R) in peritoneal endometriosis and eutopic endometrium, using immunohistochemistry. RESULTS: We detected Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. There was no significant difference in Epo expression between red and black peritoneal lesions, whereas Epo-R expression was significantly lower in black peritoneal lesions when compared to red lesions. Epo and Epo-R expression levels within red peritoneal lesions were comparable to those of eutopic endometrium from patients with endometriosis. CONCLUSION: The present findings suggest that Epo may play a role in the pathophysiology of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Erythropoietin Peritoneal Diseases Receptors, Erythropoietin Adult Endometriosis Endometrium Endometrium Erythropoietin Female Humans Immunohistochemistry Peritoneal Diseases Receptors, Erythropoietin Tissue Distribution

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