De Leo B

article 2021

Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis

Science translational medicine ·doi:10.1126/scitranslmed.abd6469

< 0.05) in a mouse model of peritoneal inflammation as well as in a mouse model of endometriosis. We conclude that the NPSR1/NPS system is a genetically validated, nonhormonal target for the treatment of endometriosis with likely increased …

article 2021

Pelvic pain correlates with peritoneal macrophage abundance not endometriosis

Reproduction & fertility ·doi:10.1530/raf-20-0072

Endometriosis is a chronic neuroinflammatory pain condition affecting ~180 million women worldwide. Surgical removal or hormonal suppression of endometriosis lesions only relieves pain symptoms in some women and symptomatic relapse followin…

review 2021

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Pain ·doi:10.1097/j.pain.0000000000002248

ABSTRACT: Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We…

other 2020

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

Scientific reports ·doi:10.1038/s41598-020-58362-3

Endometriosis is a common gynaecological disease of women in reproductive age, and is thought to arise from retrograde menstruation and implantation of endometrial tissue, mostly into the peritoneal cavity. The condition is characterized by…

article 2020

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

Scientific reports ·doi:10.1038/s41598-020-62492-z

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

preprint 2020

Peritoneal macrophage phenotype correlates with pain scores in women with suspected endometriosis

·doi:10.1101/2020.07.31.209106

Abstract Objective To characterise peritoneal macrophage populations in women with suspected endometriosis and assess if they are correlated with severity of pelvic pain symptoms. Design Flow cytometry analysis of peritoneal fluid samples a…

2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports ·doi:10.1016/j.stemcr.2018.08.007

Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discove…

2017

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor.

F1000Research ·doi:10.12688/f1000research.11432.2

Background: Human mast cells (MCs) are long-lived tissue-resident immune cells characterised by granules containing the proteases chymase and/or tryptase. Their phenotype is modulated by their tissue microenvironment. The human uterus has a…

2017

Role of mast cells in women's health and disorders of the endometrium