Pain

AbstractPeople with chronic pain can experience intrusive mental images (IMI) related to pain, that is, cognitions in the form of sensory-like experiences without actual sensory input. Previous retrospective studies suggested that such imag…

AbstractChronic pain remains a multifactorial complex common condition, difficult for patients to communicate or fully understand. We argue the arts can raise public awareness, play a role in capturing patients' subjective narratives, impro…

Predictive tools are lacking for pain-related outcomes after endometriosis surgery. The objective of this study was to develop and validate a machine learning-based clinical model to predict poor pain-related quality of life after endometri…

AbstractRecurring pain is a debilitating symptom in inflammatory bowel disease (IBD), often persisting beyond acute gut inflammation with unclear underlying mechanisms. Altered emotional reactivity to pain has been proposed as a key contrib…

Pain is a common debilitating symptom reported in people with endometriosis. Yet, we do not have a good understanding of factors that may contribute to higher pain and worse psychosocial outcomes in this population. One key construct linked…

AbstractGender minority (GM) persons have been reported to experience chronic pain at higher rates than the general population, yet comprehensive pain phenotyping in this group remains underexplored. The goal of this cross-sectional study w…

Pain is influenced by a complex interplay of biological, psychological, and social factors. Sex has emerged as a key determinant of vulnerability to chronic pain and a major risk factor for poor response to available pharmacological treatme…

Pelvic pain is a common and often debilitating experience with limited treatment options. Improving understanding of the psychosocial mechanisms involved in pelvic pain experiences will enhance the efficacy of pain management interventions.…

Chronic pelvic pain (CPP) is a common and burdensome symptom in women yet current clinical management frequently leaves many with persistent pain. The Translational Research in Pelvic Pain (TRiPP) project adopts a pain-focused strategy, aim…

AbstractAndrogens, such as testosterone, have an antinociceptive effect based on animal and adult studies. However, because androgens may exert different physiological effects during puberty, it is not clear whether the antinociceptive effe…

This study investigates whether data from people with endometriosis (n = 58) and fibromyalgia (n = 58) exhibit what is called "ergodicity," meaning that results from analyses of aggregated group data can be used to support conclusions about…

AbstractPrescription opioids for noncancer pain in the United Kingdom have increased over the past 2 decades, alongside associated harms. Policies addressing opioid prescribing must be tailored to individual patient needs with specific dise…

Dysmenorrhea affects as much as 85% of female youth in Canada and the United States and can negatively impact academic performance, overall health, and mental well-being. The physician-patient relationship can play an important role in supp…

Endometriosis is a common disorder in postpubertal women and often associated with pain in the pelvis and elsewhere. Pain and related symptoms, such as fatigue, adversely affect quality of life. Surgical and hormonal treatments have limited…

AbstractMenstrual pain is associated with deficits in central pain processing, yet neuroimaging studies to date have all been limited by focusing on group comparisons of adult women with vs without menstrual pain. This study aimed to invest…

AbstractThe aim of this review was to systematically review and meta-analyse evidence for the presence of interpretation bias in pain and to establish the likely role of interpretation bias in chronic pain. The primary questions were whethe…

AbstractResearch on social disparities in pain and pain treatment has grown substantially in recent decades, as reflected in a growing number of review articles on these topics. This scoping review of reviews provides a macrolevel overview …

Chronic overlapping pain conditions (COPCs) affect a wide population and incur a substantial disease burden including comorbid mental disorders. Although these comorbidities have been extensively documented, the longitudinal trajectories of…

AbstractRepetitive ischemia with reperfusion (I/R) injury is a common cause of myalgia. Ischemia with reperfusion injuries occur in many conditions that differentially affect males and females including complex regional pain syndrome and fi…

Limited research has examined psychological treatments for endometriosis-related chronic pain, despite its association with elevated disability, depression, and anxiety. Remotely delivered treatments have the potential to overcome barriers …

AbstractChronic pain affects one-fifth of American adults, contributing significant public health burden. Chronic pain can be further understood through investigating brain gene expression, potentially informing on brain regions, cell types…