Gao L

Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian can…

BackgroundThis study aimed to evaluate the efficacy of growth hormone (GH) as an adjuvant treatment for enhancing embryo quantity in patients with poor ovarian response (POR) who previously had no viable embryos in in vitro fertilization (I…

ObjectTo evaluate the association between hysterectomy and the risk of developing urinary incontinence (UI) based on observational studies.MethodsWe conducted a systematic search of PubMed, Embase, and Cochrane Library for observational stu…

This case explored a novel surgical method to fix levonorgestrel 52-mg intrauterine devices in patients with adenomyosis and uterine septum. The procedure is convenient and feasible, and successfully applied the technique in a 43-year-old p…

This systematic review and meta analysis was conducted to investigate the reproductive outcomes in the patients with adenomyosis after HIFU treatment, aimed to recommend HIFU treatment for those women with adenomyosis who have reproductive …

Abstract Background Adenomyosis is a chronic gynecological condition characterized by the presence of endometrial glands and stroma within the myometrium, resulting in dysmenorrhea, menorrhagia, and infertility. Objectives This study was…

BackgroundIn clinical practice, borderline seromucinous ovarian tumor (SMBT) is hard to differentiate preoperatively on ultrasound.CaseWe presented a case of SMBT. In this case, microvascular imaging, particularly three-dimensional (3D) mic…

ObjectiveTo explore the role of endometrial defects in the pathogenesis of abnormal uterine bleeding (AUB).DesignRetrospective case-control study.SettingTwo tertiary centres.Population or sampleWe included 155 patients with caesarean scar d…

OBJECTIVE: Although numerous observational studies have revealed a correlation between leukocyte telomere length (LTL) and female reproductive system diseases (RSDs), the findings of these studies have tended to be consistent. In this study…

BackgroundIschemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subty…

Introduction and hypothesisWe aimed to develop and validate a clinically applicable risk assessment model for identifying women at a high risk of pelvic organ prolapse (POP) based on a retrospective practice.MethodsThis study enrolled patie…

ObjectiveTo explore the micro blood flow characteristics of normal singleton pregnancy placenta in middle and late pregnancy based on microvascular flow (MV-Flow) imaging.MethodsWe conducted a retrospective cohort study. Clinical records an…

Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some common botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities. In this paper, we sys…

PurposeTo screen drug targets of ovarian aging from a genetic perspective.MethodsSystematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statistics we…

Oral dysbiosis increases the risk of oral diseases and systemic diseases, with many related conditions overlapping with systemic diseases triggered by gut dysbiosis. Studies have shown that the oral cavity serves as an endogenous reservoir …

BackgroundAlthough many studies have validated the diagnostic performance of Ovarian-Adnexal Reporting and Data Systems ultrasound (O-‎RADS US), most have been observed by experienced sonologists, and relatively few by junior sonologists. T…

ObjectiveTo assess the efficacy of preimplantation genetic testing for aneuploidies (PGT-A) compared to intracytoplasmic sperm injection (ICSI) alone in couples undergoing ICSI treatment because of severe male infertility.DesignMulticentre,…

BACKGROUND: Premature ovarian insufficiency (POI) is a condition identified by the decline in ovarian function before the age of 40. The treatment of POI patients deserves in-depth research. This study aimed to explore the impacts of probio…

While the blood urea nitrogen/albumin ratio (BAR) is recognized for its prognostic significance in various diseases, its association in acute pancreatitis (AP) remains uncertain. This research seeks to clarify the relationship between BAR a…

IntroductionThe Systemic Immune-Inflammation Index (SII) is a novel biomarker that has been implicated in the pathogenesis of various neoplastic and non-neoplastic diseases. This study aimed to evaluate the association between SII and the c…

SEM) group was duplicated from the second panel of 5B (SCEA) group.Additionally, the third panel of 5B (SCEA group) was partially duplicated from the first panel of 5C (SCEB group).The original Figure 5 and accompanying legend appear below.

Premature ovarian insufficiency (POI) is defined as the depletion of ovarian function before the age of 40 years. The global prevalence of POI is 3.5%. To date, genetic factors account for 23.5% of the etiology of POI. Herein, a previously …

MotivationExploring potential associations between diseases can help in understanding pathological mechanisms of diseases and facilitating the discovery of candidate biomarkers and drug targets, thereby promoting disease diagnosis and treat…

ObjectiveThe incidence of Polycystic Ovary Syndrome (PCOS) is increasing annually. This study aims to investigate the therapeutic mechanisms of Yikang Decoction (YKD) in the treatment of PCOS through the integration of GEO datasets, network…

IN BRIEF: Elevated expression of miR-122-5p in exosomes in the follicular fluid of patients with endometriosis impairs glucose metabolism in cumulus cells and may further impair oocyte quality. ABSTRACT: Endometriosis (EMs) affects fertili…