Yan Li

目的探讨整合素B1（Intβ1）、基质金属蛋白酶-2（MMP-2）及促肝细胞再生磷酸酶．3（PRL．3）在子宫内膜异位症（EMS）中的表达。方法选取EMS患者异位内膜30例、在位内膜20例和子宫肌瘤患者非瘤区子宫内膜组织20例（对照内膜），应用免疫组织化学方法检测各组织中Intβ1、MMP-2及PRL-3的表达水平。结果Intβ1、MMP-2和PRL-3在异位内膜中的表达明显高于在位内膜和对照内膜（P均〈0．01）。在对照内膜分泌期Intβ1表达强于增生期（P〈0．05）；在…

BACKGROUND: Adenomyosis is a common gynecological disease, which is accompanied by a series of immunological and neuroendocrinological changes. Nerve growth factor (NGF) plays a critical role in producing pain, neural plasticity, immunocyte…

Objective:To give some new theoretical basis and treatment methods for different individual of EMs,not only to discuss the differences appearing in different individual endometrial in uPAR and LN,but also to discuss the differences may have…

BACKGROUND: Angiogenesis appears to be an important event in the pathophysiology of endometriosis (EM) and adenomyosis. Two angiogenic factors, fibroblast growth factor (FGF) 1 and 2, play a central role in the initiation of angiogenesis. W…

Objective: To explore the clinical application of hysteroscopy combined with laparoscopy in diagnosis and treatment of chronic pelvic pain ( CPP) . Methods: 80 patients with CPP were diagnosed and treated by laparoscopy and hysteroscopy,ult…

Over the years development of selective estrogen receptor (ER) ligands has been of great concern to researchers involved in the chemistry and pharmacology of anticancer drugs, resulting in numerous synthesized selective ER subtype inhibitor…

BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the development of endometriosis. The aim of this study was to investigate the association of polymorphisms in the VEGF gene with the susceptibility to endomet…

OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNPs) in VEGF gene with the risk of endometriosis and adenomyosis. METHODS: Genotypes were analyzed by polymerase chain reaction-restriction fragment length poly…

子宫内膜异位症(内异症)和子宫腺肌病(腺肌病)为妇科常见疾病,但其病因及发病机制尚不明确.虽为良性疾病,但具有周围浸润、远处转移和种植的恶性行为,其中血管生成在子宫内膜异位种植的过程中起重要作用。

Vascular endothelial growth factor (VEGF), a major mediator of angiogenesis and vascular permeability, may play a key role in the development of adenomyosis. The aim of this study was to investigate whether these four VEGF polymorphisms (-2…

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-…

Objective To investigate the expression of transforming growth factor-β1(TGF-β1)and matrix metalloproteinase-2(MMP-2) in the ectopic endometrium of adenomyoma and their relation with the pathogenesis of adenomyoma.Methods Endometrial specim…

The matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) i…

OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNPs) in matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) with the risk of endometriosis and adenomyosis. METHODS: Genotyp…

Objective To measure the levels of prostaglandins(PGE2,TXB2)in biopsy specimens from patients with endometriosis,and explore the relationship between prostaglandin level and the severity of pain.Methods The expression of PGE2,TXB2 protein w…

Objective To investigate the expression of vascular endothelial growth factor (VEGF)and tumor necrosis factor-α (TNF-α) in the ectopic endometrium of adenomyoma and their relation with the pathogenesis of adenomyoma.Methods Endometrial spec…

Endometriosis, one of the most frequent diseases in gynecology, is a benign but invasive and metastatic disease. The altered expression of E-cadherin may play an important role in developing endometriosis. In this paper, we discuss the asso…

OBJECTIVE: To investigate mRNA expression of matrix metalloproteinase (MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) in ectopic endometriosis tissue and uterine endometrium from women with and without endometriosis. METHODS: Th…

Objective: To investigate the cause, pathogenesis and the clinical-pathologic char- acteristics of endometriosis. Method: According to the area of lesion endometriosis is divided into (1) adenomyosis (also named interna endometriosis, IEM )…

Objective To evaluate the effects of conjugated equine estrogens (CEE) in estrogen replacement therapy (ERT) following total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH with BSO) for the treatment of endometriosis. Meth…

OBJECTIVE: To investigate the association of the matrix metalloproteinases (MMP) 1, 3 promoter single nucleotide polymorphism (SNP) with the susceptibility to endometriosis (EM) and adenomyosis. METHODS: The SNP of the MMP-1 and MMP-3 gene…

Matrix metalloproteinases (MMPs) may contribute to the development of endometriosis. Genetic variations in several MMP promoters may influence the transcription and expression of MMPs. The purpose of the present study was to assess how gene…