van Langendonckt A

ObjectiveTo identify metabolites that are associated with and predict the presence of endometriosis.DesignMetabolomics study using state-of-the-art mass spectrometry approaches.SettingUniversity hospital and universities.Patient(s)Twenty-fi…

PurposeTo review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics.MethodsRetrospective longitudinal analysis of data from a…

ObjectiveTo evaluate, in peritoneal, ovarian, and rectovaginal endometriotic lesions, expression of steroidogenic enzymes involved in the activation and inactivation of estrogens: 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) and 2 (HSD…

PurposeTo assess the safety of reimplantation of cryopreserved ovarian tissue from advanced-stage breast cancer patients.MethodsCryopreserved ovarian cortical fragments were obtained from 13 advanced-stage breast cancer patients aged 17-35 …

ObjectiveTo study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure.DesignExperimental animal study.SettingAca…

ObjectiveTo establish an experimental model for the study of deep nodular endometriosis.DesignInduction of nodular endometriosis in baboons by grafting different uterine specimens to the peritoneal cavity.SettingResearch and university faci…

ObjectiveTo evaluate the adverse effects of endometriomas on ovarian reserve.DesignAnalysis of prospectively collected biopsy samples.SettingGynecology research unit in a university hospital.Patient(s)Women younger than age 35 years with en…

BACKGROUND: Steroid sulfatase (STS) is involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of disease-free and endometriosis patients. The present study was designed to investigate its role in endometriosis de…

Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometri…

ObjectiveTo determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons.DesignInduction and follow-up of endometriosis in baboons, which is one of the primate …

Peritoneal endometriosis is a chronic inflammatory disease characterized by increased numbers of peritoneal macrophages and their secreted products. Inflammation plays a major role in pain and infertility associated with endometriosis, but …

ObjectiveTo compare expression of homeobox A (HOXA) genes involved in the differentiation of the female reproductive tract in deep endometriotic nodules and peritoneal lesions.DesignProspective experimental study.SettingAcademic gynecology …

ObjectiveTo evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis.DesignA literature search was conducted in PubMed to identify all relevant citations.Result(s)Our findings highlight the important role of NF-κB…

BACKGROUND: Aromatase has been reported to be involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of endometriosis patients. The objective of the present study was to investigate its expression and localizatio…

BACKGROUND/AIMS: Endometriosis is known to be an estrogen-dependent disease. However, only a few studies have analyzed the effect of estrogen treatment in mice xenotransplanted with human endometrium. The objective of this study was to adap…

BACKGROUND: Increased peritoneal eicosanoid concentrations have been reported in endometriosis patients and might be important in disease-associated pain and inflammation. Here, we evaluated the expression of key biosynthetic and catabolic …

Classic murine endometriosis models may be insufficient to evaluate the effect of therapeutic agents on endometriosis development, because the process of identification and measurement of induced lesions is often impeded, as implants are sm…

It is widely known that angiogenesis plays a key role in endometriotic lesion formation and development. Antiangiogenic treatments aimed at inhibiting new vessel formation have proven efficient in experimental models. However, as antiangiog…

ObjectiveTo further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls.DesignCross-sectional study.SettingAcademic gynecology rese…

The aim of this study is to review the current literature associating endometriosis with iron and to discuss the potential causes and consequences of iron overload in the pelvic cavity. Indeed, iron is essential for all living organisms. Ho…

BACKGROUND/AIMS: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. METHODS: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometrio…

BACKGROUND: In vitro studies suggest that the transcription factor nuclear factor-kappa B (NF-kappaB) is implicated in the transduction of proinflammatory signals in endometriosis. The aim of this study was to investigate the involvement of…

BACKGROUND: Estradiol (E(2)) is an important promoter of the growth of both eutopic and ectopic endometrium. The findings with regard to the expression and activity of steroidogenic enzymes in endometrium of controls, in endometrium of endo…

To identify specific markers of rectovaginal endometriotic nodule vasculature, highly enriched preparations of vascular endothelial cells and pericytes were obtained from endometriotic nodules and control endometrial and myometrial tissue b…

Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors. Our results show that activation…