Huang J

BACKGROUND: Endometriosis and major depressive disorder (MDD) pose significant global health burdens. Despite pathophysiological overlaps, existing epidemiological studies predominantly examine their unidirectional associations, often const…

BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) impose significant clinical and economic burdens on healthcare systems globally. Patients in obstetrics and gynecology face unique vulnerabilities; however, population-specif…

BACKGROUND: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing In Vitro Fertilization or Intracytoplasmic Sperm Injection after ultrasound-guided ethanol scle…

STUDY QUESTION: What is the optimal timing of progesterone exposure to achieve live births for day-6 blastocysts in artificial frozen-thawed embryo transfer (FET) cycles? SUMMARY ANSWER: Live birth rates (LBRs) were comparable between day-…

Decidualization of human endometrial stromal cells (HESCs) is one of the critical steps in the establishment of human pregnancy. Nevertheless, little is known about the molecular mechanisms underlying human decidualization. In this study, w…

BACKGROUND: Inflammation is central to the pathogenesis of endometriosis. High-density lipoprotein (HDL)-related lipid ratios have been proposed as indicators of systemic metabolic inflammation, yet their associations with endometriosis sta…

Severe pneumonia is the leading cause of mortality in individuals with lung disease. Programmed cell death (PCD) is implicated in various pathologies; however, the precise relationship between severe pneumonia and PCD remains unclear. This …

This study explores how quercetin may treat endometriosis (EMs) by combining network pharmacology and transcriptome sequencing approaches. Through network pharmacology, 132 shared targets between quercetin and EMs were identified, with KEGG…

BACKGROUND: Endometrial receptivity (ER) serves as a critical determinant for successful embryo implantation, yet its molecular complexity and limited clinical assessment methods pose significant challenges. Despite advancements in assisted…

BACKGROUND: Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women. In livestock production, improper management may disturb livestock eating and act…

BackgroundCervical clear cell adenocarcinoma (CCAC) and cervical endometrioid adenocarcinoma (CEAC) are rare and aggressive non-HPV-associated malignancies. Despite their histological similarities, these subtypes demonstrate distinct biolog…

Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully unde…

BACKGROUND: LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharm…

Pregnant women undergoing assisted reproductive technology (ART) have an increased risk of gestational diabetes mellitus (GDM), potentially linked to altered immune regulation, but the underlying circulating immune features remain unclear. …

BACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium duri…

BackgroundImplantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful implant…

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder and a major cause of female infertility. While epigenetic dysregulation, notably DNA methylation, has been recognized as a key driver of PCOS pathogenesis, the specific involv…

BACKGROUND: This study utilizes data from two principal sources: the National Health and Nutrition Examination Survey (NHANES) conducted in the United States from 1999 to 2020 and the China Health and Retirement Longitudinal Study (CHARLS) …

PurposeTo investigate the impact of regressed endometrial hyperplasia (EH) on assisted reproductive technology outcomes, particularly in comparison with infertile women with a relatively normal endometrium.MethodsThis retrospective study in…

N6-methyladenosine (m6A) is a critical regulator of female reproductive physiology, yet existing reviews have focused predominantly on oocytes. The objective of this review is to systematically evaluate the regulatory effects of m6A through…

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have…

Tumor immune escape is a major challenge in cancer treatment, and targeted immune escape therapy has become a key strategy for cancer treatment. As an important deubiquitinating enzyme, ubiquitin-specific protease 10 (USP10) participates in…

ETHNOPHARMACOLOGICAL RELEVANCE: Xiao-Liu Tang (XLT), a formulation grounded in the Traditional Chinese medicine (TCM) theory of Qi-Blood, has shown promise in alleviating endometriosis-related symptoms through clinical observations, with em…

Abdominal pregnancy is a special type of ectopic pregnancy that require careful evaluation for accurate diagnosis and appropriate management. Detailed clinical presentations, surgical procedures, and histopathological examinations of five c…

Currently, hormonal therapy for endometriosis faces challenges in achieving a balance between treatment and preserving the chance of pregnancy. Therefore, the development of non-hormonal therapy holds significant clinical importance. Angiog…