W. Glenn McCluggage

Endometriosis is an extremely common condition and, in most cases, establishing a histological diagnosis is straightforward, although a variety of benign alterations may result in problems with interpretation. In this review, I discuss sele…

In most cases of suspected endometrial neoplasia tumor origin can be correctly assigned according to a combination of clinical, radiologic, and pathologic features, even when the latter are based upon the examination of relatively small bio…

Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate p…

Accurate staging of cancers is an important determinant of prognosis and guides optimal patient treatment. Although the International Collaboration on Cancer Reporting recommends that endometrial cancers (including carcinosarcomas) are path…

Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinom…

Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasi…

GATA3 is a transcription factor critical for embryogenesis, development, and cell differentiation. Recent studies have suggested that GATA3 is a sensitive and relatively specific biomarker for urothelial and breast carcinomas, with most Mül…

Seromucinous neoplasms are a new category of ovarian epithelial tumor in the revised World Health Organization Classification of Tumours of the Female Reproductive Organs. Borderline variants are well described, but there have been few repo…

Ovarian endometrioid adenocarcinomas may have an extremely variable morphologic appearance and mimic a number of other epithelial malignancies as well as nonepithelial tumors. We report the clinicopathologic features of a small series of ov…

Primary intestinal-type glandular lesions of the vagina are rare. We report a series of 14 lesions, including 1 intestinal-type polyp without neoplastic features, 3 adenomas (2 with high-grade dysplasia), and 10 adenocarcinomas. Patients ra…

AIMS: To look for FOXL2 mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (AGCT). METHODS AND RESULTS: We report the 402C→G FOXL2 mutation status in five epith…

Intravascular leiomyomatosis (IVL) is characterized by the presence of smooth muscle in venous and lymphatic spaces within the myometrium. Although the intravascular component usually consists solely of typical smooth muscle or variants of …

Stromal myxoid change is a rare feature of non-neoplastic disease of the uterus. "Myometrial myxoidosis" with secondary myometrial hypertrophy was reported in 2 patients with systemic lupus erythematosus. Uterine myxoid stromal change was a…

We report 2 cases of primary vaginal mucinous adenocarcinoma arising in adenosis in nondiethylstilbestrol-exposed women, 1 with uterus didelphys. Both tumors exhibited morphologic and immunohistochemical features (MUC6 and/or HIK 1083 posit…

Endometriosis is a common condition in women of reproductive age and has a known propensity to involve abdominal wall scars. The authors report 2 cases of endometriosis presenting as mass lesions involving the abdominal wall at the site of …

Intestinal metaplasia of the endometrium is extremely uncommon with only a single earlier case report. We describe 2 cases of endometrial intestinal metaplasia, one of them involving an endometrial polyp, characterized by the presence of in…

Ovarian carcinomas comprise a heterogeneous group of neoplasms, the four most common subtypes being serous, endometrioid, clear cell and mucinous. In recent years, our understanding of the underlying pathogenesis and initiating molecular ev…

Uterine adenosarcomas are uncommon mixed Müllerian neoplasms, most commonly arising in the uterine corpus. A new Federation of International Gynecologic Organization staging system for these tumors has recently been implemented. This stagin…

AIMS: To describe the clinicopathological features of florid peritoneal mesothelial hyperplasia associated with gynaecological disease. METHODS: Review of a series of 44 cases where there was significant peritoneal mesothelial proliferatio…

The presence of signet ring cells in a carcinoma within the uterine corpus strongly raises the possibility of a metastasis from a primary tumor in the breast, gastrointestinal tract, or elsewhere. Signet ring cells are extremely rare in pri…

The occurrence of vascular involvement in adenomyosis has been noted earlier, but there has been little detailed study of this phenomenon. In this study, we examined a large series of uteri with adenomyosis (n=434), specifically looking for…

BACKGROUND: Both actinomycotic granules and pseudoactinomycotic radiate granules (PAMRAGs) occur in the female genital tract, most commonly in the endometrium. It is important to distinguish between these since the former may result in pelv…

AIMS: To describe a series of endometrial stromal sarcomas with large numbers of endometrioid-type glands. METHODS AND RESULTS: The eight tumours occurred in patients aged 42-74 years. In three cases, the neoplasm arose in the uterine corp…