Endometrial Adenocarcinoma With Signet Ring Cells

Boyd C, Clinton Boyd, Cameron I, Iain Cameron, McCluggage WG, W. Glenn McCluggage
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2010 · vol. 29(6) , pp. 579–582 · doi:10.1097/pgp.0b013e3181e20c66 · PMID:20881852 · W2066999270
article OA: closed CC0
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-13 ⓘ

This report describes two cases of primary endometrial adenocarcinoma with signet ring cells, one arising within adenomyosis, demonstrating that this histology does not necessarily indicate metastasis from other sites.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-01 · read from full text ⓘ

This case report describes two rare instances of primary endometrial adenocarcinoma characterized by the presence of signet ring cells, a feature that typically suggests metastasis from other sites such as the breast or gastrointestinal tract. The authors present one case of mucinous type and another of endometrioid type, noting that one of the tumors developed within an area of adenomyosis. They conclude that identifying signet ring cells does not automatically rule out a primary endometrial origin, challenging the common diagnostic assumption that such morphology indicates secondary spread. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

The presence of signet ring cells in a carcinoma within the uterine corpus strongly raises the possibility of a metastasis from a primary tumor in the breast, gastrointestinal tract, or elsewhere. Signet ring cells are extremely rare in primary endometrial adenocarcinomas with only a single prior case report. We report 2 cases of primary endometrial adenocarcinoma, one of mucinous and the other of endometrioid type, with a significant component of signet ring cells. One of the neoplasms arose within adenomyosis. In reporting these cases, we illustrate that the presence of signet ring cells does not preclude a primary endometrial adenocarcinoma.We discuss signet ring cells in the endometrium.
Full text 1,082 characters · extracted from oa-doi-fallback · click to expand
PATHOLOGY OF THE CORPUS: ORIGINAL ARTICLES Endometrial Adenocarcinoma With Signet Ring Cells Report of Two Cases of an Extremely Rare Phenomenon - Clinton Boyd - Iain Cameron - W. Glenn McCluggage International Journal of Gynecological Pathology 29(6):p 579-582, November 2010. | DOI: 10.1097/PGP.0b013e3181e20c66 The presence of signet ring cells in a carcinoma within the uterine corpus strongly raises the possibility of a metastasis from a primary tumor in the breast, gastrointestinal tract, or elsewhere. Signet ring cells are extremely rare in primary endometrial adenocarcinomas with only a single prior case report. We report 2 cases of primary endometrial adenocarcinoma, one of mucinous and the other of endometrioid type, with a significant component of signet ring cells. One of the neoplasms arose within adenomyosis. In reporting these cases, we illustrate that the presence of signet ring cells does not preclude a primary endometrial adenocarcinoma. We discuss signet ring cells in the endometrium. Copyright ©2010International Society of Gynecological Pathologists

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

adenomyosis

MeSH descriptors

Carcinoma, Signet Ring Cell Endometrial Neoplasms Carcinoma, Signet Ring Cell Endometrial Neoplasms Female Humans Middle Aged

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (14)

Source provenance

europepmc
last seen: 2026-09-15T06:16:59.523076+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:17:00.782903+00:00
unpaywall
last seen: 2026-09-15T06:33:26.365676+00:00
License: CC0 · commercial use OK