{"paper_id":"53091b13-80e4-429a-8ac6-3e177d434bd3","body_text":"PATHOLOGY OF THE CORPUS: ORIGINAL ARTICLES\nEndometrial Adenocarcinoma With Signet Ring Cells\nReport of Two Cases of an Extremely Rare Phenomenon\n- Clinton Boyd\n- Iain Cameron\n- W. Glenn McCluggage\nInternational Journal of Gynecological Pathology 29(6):p 579-582, November 2010. | DOI: 10.1097/PGP.0b013e3181e20c66\nThe presence of signet ring cells in a carcinoma within the uterine corpus strongly raises the possibility of a metastasis from a primary tumor in the breast, gastrointestinal tract, or elsewhere. Signet ring cells are extremely rare in primary endometrial adenocarcinomas with only a single prior case report. We report 2 cases of primary endometrial adenocarcinoma, one of mucinous and the other of endometrioid type, with a significant component of signet ring cells. One of the neoplasms arose within adenomyosis. In reporting these cases, we illustrate that the presence of signet ring cells does not preclude a primary endometrial adenocarcinoma. We discuss signet ring cells in the endometrium.\nCopyright ©2010International Society of Gynecological Pathologists","source_license":"CC0","license_restricted":false}