Endometrial Intestinal Metaplasia

Alina Nicolae, Pablo Goyenaga, W. Glenn McCluggage, Ovidiu Preda, Francisco F. Nogales
In: International Journal of Gynecological Pathology · 2011 · vol. 30(5) , pp. 492–496 · doi:10.1097/pgp.0b013e318211d586 · PMID:21804398 · W2314740135
article OA: closed CC0 ⤵ 2 in-corpus citations
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This paper reports two cases of endometrial intestinal metaplasia, characterized by intestinal-type epithelium, and suggests a possible association with cervical intestinal metaplasia.

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Abstract

Intestinal metaplasia of the endometrium is extremely uncommon with only a single earlier case report. We describe 2 cases of endometrial intestinal metaplasia, one of them involving an endometrial polyp, characterized by the presence of intestinal-type epithelium containing goblet and neuroendocrine cells, which were positive with CK20, CDX2, chromogranin, and villin. In 1 case, there was concomitant intestinal and pyloric metaplasia in the endocervix. Together with the observation of the earlier reported case of endometrial intestinal metaplasia, there was also intestinal metaplasia in the cervix. This suggests a possible association between intestinal metaplasia at different sites in the female genital tract.

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