Byung Seok Lee

background: Recently, proteomic technologies have demonstrated that several proteins are differently expressed in various body fluids of patients with endometriosis compared with those without this condition. The aim of this study was to in…

Endometriosis is an enigmatic disease characterized by development of endometrial tissue outside of the uterus, causing pain and infertility. This guideline will provide evidence based information concerning diagnosis and treatment of endom…

Because energy production involves oxidative phosphorylation, mitochondria are major sources of reactive oxygen species in the cell. Recent findings indicate that mitochondrial DNA (mtDNA) variants may play a role in the etiology of certain…

The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to inve…

BACKGROUND: Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) is involved in cellular processes such as inflammation, apoptosis and tumorigenesis. However, little is known about the expression and function of NAG-1 in th…

월경과다는 산부인과 일차 진료에서 매우 흔한 문제로서 많은 여성들의 삶의 질을 저하시킬 수 있다. 본 진료지침은 임상근거자료에 의거하여 월경과다의 진단과 치료에 관한 지식을 제공하여 임상의들이 월경과다 환자에게 제공하는 진단 권고사항 및 치료 권고사항에 신뢰성을 부가하고 임상의의 판단과정에 자신감을 부여하는 근본이 되기 위함이다. 월경과다 환자의 치료로써 기존에 연구되었던 다양한 치료방법들에 관해 연구결과들을 바탕으로 그 효과…

BACKGROUND: Oxidative stress is considered to be involved in the establishment and development of endometriosis. Thioredoxin (TRX) is an endogenous redox regulator that protects cells against oxidative stress, and TRX-binding protein-2 (TBP…

Background Oxidative stress is considered to be involved in the establishment and development of endometriosis. Thioredoxin (TRX) is an endogenous redox regulator that protects cells against oxidative stress, and TRX-binding protein-2 (TBP-…

만성 골반통증이나 불임을 유발하는 가장 흔한 부인과적 질환 중 하나인 자궁내막증은 자궁내막 조직이 정상 자궁 위치를 벗어나 자궁강 밖에 존재 하는 질환으로 정의할 수 있다. 자궁내막증은 흔히 난소나 골반 복막에서 발견되나 장, 방광, 요관은 물론이고 골반 밖 장기인 폐에서도 진단되며 전형 적으로 복강경을 통한 수술적 방법으로 확진을 하 게 되나 증상이 없는 사람에서도 자궁내막증이 있 을 수 있다. 증상의 유무와 상관없이 자궁내…

PROBLEM: The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels in patients with endometriosis. METHOD OF STUDY: A total of 79 patients with histologically confirmed endometrios…

BACKGROUND/AIMS: The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameter…

OBJECTIVE: The aim of this study was to evaluate the long-term clinical effects of a levonorgestrel-releasing intrauterine device (LNG-IUD) on adenomyosis. STUDY DESIGN: A LNG-IUD was inserted into 47 patients who were diagnosed with adeno…

Objective: This study was designed to compare the effects of laparoscopic total hysterectomy and laparoscopic supracervical hysterectomy on female sexual quality. Methods: A Prospective observational study over 6 months was performed. Ninet…

OBJECTIVE: To investigate the clinical value of differential white blood cell counts and neutrophil-to-lymphocyte ratio (NLR), by themselves or as adjunct to CA-125, in the diagnosis of endometriosis. DESIGN: Retrospective study. SETTING:…

BACKGROUND: This study was performed to determine whether genetic polymorphisms of aryl hydrocarbon receptor repressor (AhRR), glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) are associated with susceptibility …

PURPOSE: This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) in women with climacteric symptoms, and to assess their effects on vaginal atrophy, hormone level…

PROBLEM: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-alpha (TNF-alpha), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. METHOD O…

Endometriosis—the implantation of endometrial tissue outside its normal uterine location—may occur in as many as 15% of women of reproductive age, but its pathogenesis still is not fully understood. Conceivably the affected endometrium has …

BACKGROUND: Endometriosis is considered a frequent, benign disease with the ability to undergo neoplastic processes. The aim of this study was to evaluate the limitless replication potential of the endometrium in patients with endometriosis…

Objective : This study was undertaken to evaluate the cell cycle signaling pathway by cyclins-cyclin dependent kinases (CDKs) and cyclin dependent kinase inhibitors (CDKIs) in endometriosis. Methods : 38 women with endometriosis were recrui…