The hyperexpressions of putative stem cells in the eutopic endometrium of patients with advanced endometriosis
This guideline provides evidence-based knowledge for the diagnosis and treatment of abnormal uterine bleeding, reviewing various treatment methods' effects, risks, and benefits to aid clinicians in selecting rational and effective therapies.
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This paper is a clinical practice guideline that reviews evidence on the evaluation and management of heavy menstrual bleeding (menorrhagia), focusing on women with repetitive heavy regular cycles and excluding acute anovulatory bleeding presentations. It synthesizes research on diagnostic workup (history, pelvic exam, CBC for anemia/thrombocytopenia, and imaging such as pelvic ultrasound, saline infusion hysterography, hysteroscopy, and selective CT/MRI) and summarizes comparative effectiveness and adverse effects for first- and second-line medical therapies, including LNG-IUS, tranexamic acid, combined oral contraceptives, NSAIDs, and progestogens, along with surgical options. The guideline explicitly notes that certain recommendations rely on guideline evidence grading and comparative limitations (e.g., many imaging studies were conducted in anovulatory bleeding cohorts, and LNG-IUS effects may require at least 6 months to judge). This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (4)
- Randomized Trial of 2 Hormonal and 2 Prostaglandin‐inhibiting Agents in Women with a Complaint of Menorrhagia 1991
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 1998
- Danazol for heavy menstrual bleeding 2007
- Treating Menorrhagia in Primary Care: <i>An Overview of Drug Trials and a Survey of Prescribing Practice</i> 1995
References (35)
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