М.Р. Оразов

Актуальность: Эндометриоз остаётся одной из ведущих причин нарушений фертильности вследствие сочетанного влияния на овариальный резерв, качество ооцитов, рецептивность эндометрия и иммунные механизмы. Цель исследования – обобщить современны…

Today, both adenomyosis and endometriosis are at the forefront of scientific debate. The kinship of adenomyosis and endometriosis at first glance still raise no doubts, since there is reliable scientific evidence of the fact that the pathog…

Chronic endometritis is widespread among women of reproductive age, it can be the cause of menstrual disorders, abnormal uterine bleeding and, finally, infertility of uterine genesis. The issue of impaired immune status of the glandular-str…

The global relevance of endometriosis as one of the most common gynaecological nosologies is increasing every year. Currently available evidence-based data help to uncover the most intimate pathogenetic stigmas of the disease and identify k…

Abnormal uterine bleeding (AUB) remains one of the most common gynecological disorders that reduce the quality of life and reproductive potential in women. Obesity is recognized as an independent risk factor for the development of AUB assoc…

Endometriosis continues to be an unsolved/unsolvable problem of modern gynecology. There are only 3 most common clinical phenotypes of this disorder: superficial peritoneal endometriosis, cystic ovarian endometriosis and deeply infiltrative…

The endometrium is one of the most dynamic tissues that constantly undergoes changes during the menstrual cycle in women of the reproductive period. All these processes take place mainly under the influence of steroid hormones that are prod…

Background. Infertility tends to become one more modern pandemic. According to some estimates, the percentage of infertile couples varies between 10–25% (48–180 million). Such couples face adverse effects on their physical and mental health…

This article provides a literature review on the etiopathogenesis of endometriosis. Particular attention was paid to genetic and molecular biological aspects of endometriosis. The issues of conservative management of patients with confirmed…

Today, endometrial hyperplasia (EH) is among the most relevant gynecological entities. Arterial hypertension, diabetes mellitus and obesity, the combination of which is referred to as metabolic syndrome, are the key risk factors of EH. The …

The prevalence of endometriosis is still high and amounts to 10% of women of reproductive age in the population; unfortunately, there is a continuing negative trend towards its increase. Early reproductive losses in endometriosis contribute…

Objective. To study the effectiveness of therapy with dienogest (Zafrilla) in the prevention of ovarian endometriosis recurrence after surgical treatment. Patients and methods. This prospective observational comparative study enrolled 104 p…

Objective. Analytical review of the literature on endometriosis-associated infertility, its mechanisms and hormone therapy in preparation for in vitro fertilization (IVF). Endometriosis is considered the most common benign but potentially m…

OBJECTIVE: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. METHODS: A systematic literature review regarding curre…

Endometriosis remains an unresolved problem in gynecology. The urgency of the fight against this disease is due to its high prevalence among women of reproductive age. Endometriosis, especially its infiltration forms, affects all aspects of…

Study Objective: To study impaired expression of estrogen (ER) and progesteron (PR) receptor isoforms during the implantation window in eutopic endometrium of infertile women associated with endometriosis genitalis externa (EGE). Study Desi…

Endometriosis is a chronic inflammation condition which is associated with adhesive processes in the small pelvis and pelvic pain syndrome. The pathogenesis of adhesions has similar components to the mechanism of endometrioid heterotopia. A…

Uterine leiomyoma, along with endometriosis, occupies a leading position in the structure of gynecological diseases associated with hyperproliferation. The disease can negatively affect the reproductive potential, gynecological health, soma…

OBJECTIVE: The aim of the study was to expand the understanding of pathogenesis of adenomyosis-associated pelvic pain. MATERIAL AND METHODS: We studied 30 (n = 30) biopsy samples obtained after hysterectomy in women with diffuse adenomyosis…

Aim Endometriosis is one of the most common gynecological diseases diagnosed in almost 70% of patients with chronic pelvic pain (CPP). However, a quarter of women with pelvic pain is diagnosed with external genital endometriosis (EGE) durin…