Combined treatment (surgery + hormone therapy) of patients with various forms of endometriosis

In: Clinical review for general practice · 2024 · vol. 5(3) , pp. 39–46 · doi:10.47407/kr2023.5.3.00372 · W4400084680
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This review covers the key pathogenetic mechanisms of deep infiltrative, superficial peritoneal, and endometrioid ovarian cyst endometriosis and highlights current combined treatment strategies.

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This narrative review discusses key pathogenetic mechanisms across major phenotypes of endometriosis—deep infiltrative disease, superficial peritoneal endometriosis, and endometrioid ovarian cysts—and frames how these differences inform combined treatment strategies that integrate surgery with hormone therapy. The paper highlights dienogest among hormone-therapy approaches and emphasizes an evidence-based approach for identifying key treatment targets. A major caveat is that, as a review, it does not present new primary patient data or a specific comparative trial design for the combined regimen. This paper is centrally about endometriosis — it reviews surgery plus hormone therapy across different endometriosis phenotypes.

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Abstract

The global relevance of endometriosis as one of the most common gynaecological nosologies is increasing every year. Currently available evidence-based data help to uncover the most intimate pathogenetic stigmas of the disease and identify key application points for its treatment. That said, the most common forms of endometriosis are currently deep infiltrative, superficial peritoneal, and endometrioid ovarian cysts. This review presents the key pathogenetic mechanisms of different phenotypes of the disease and highlights current strategies for their combined treatment.
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Abstract

The global relevance of endometriosis as one of the most common gynaecological nosologies is increasing every year. Currently available evidence-based data help to uncover the most intimate pathogenetic stigmas of the disease and identify key application points for its treatment. That said, the most common forms of endometriosis are currently deep infiltrative, superficial peritoneal, and endometrioid ovarian cysts. This review presents the key pathogenetic mechanisms of different phenotypes of the disease and highlights current strategies for their combined treatment.

Keywords

superficial peritoneal endometriosis, deep infiltrative endometriosis, endometrioid ovarian cysts, dienogest. About the Author Mekan R. Orazov 1 , Viktor E. Radzinsky 1 , Evgeny D. Dolgov 11 People’s Friendship University of Russia (RUDN University), Moscow, Russia

References

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For citation:Orazov M.R., Radzinsky V.E., Dolgov E.D. Combined treatment (surgery + hormone therapy) of patients with various forms of endometriosis. Clinical review for general practice. 2024; 5 (3): 39–46. (In Russ.). DOI: 10.47407/kr2023.5.3.00372 All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

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