Infiltrative endometriosis and adhesions: is there a cause-and-effect relationship?

М.Р. Оразов, Ljudmila M. Mihaleva, Madina A. Bekulova
In: Gynecology · 2021 · vol. 23(2) , pp. 198–204 · doi:10.26442/20795696.2021.2.200743 · W3167361093
article OA: gold CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigates the potential cause-and-effect relationship between infiltrative endometriosis and adhesions, highlighting similarities in their pathogenesis and suggesting proteolytic enzymes as a beneficial treatment addition.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This Best Practice article examines whether a cause-and-effect relationship exists between infiltrative endometriosis and pelvic adhesions by comparing proposed shared pathogenic mechanisms, including chronic estrogen-dependent inflammation, altered adhesion/invasion pathways (e.g., laminins, MMPs), immune imbalance, and contributions of microbial stimuli and DAMP/NF-κB signaling. It describes how adhesion formation is driven by impaired fibrinolysis in chronic inflammation, with key roles for tPA, VEGF, and plasminogen activator inhibitors such as PAI-1, including a reported Russian association of the SERPINE1 4G/4G promoter polymorphism with endometriosis (17% vs control, p<0.01). The major limitation is that the paper is largely a narrative review of mechanisms and related findings rather than presenting original empirical data or a direct causal test. This paper is centrally about endometriosis — specifically, it argues about possible cause-and-effect links between infiltrative endometriosis and pelvic adhesion formation.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a chronic inflammation condition which is associated with adhesive processes in the small pelvis and pelvic pain syndrome. The pathogenesis of adhesions has similar components to the mechanism of endometrioid heterotopia. A comprehensive approach to the treatment of infiltrative endometriosis proves its effectiveness and is the most rational for this cohort of patients. The use of proteolytic enzymes, which has long been included in clinical practice, is a pathogenetically reasonable addition to the pharmacological strategy in obstetrician-gynecologist practice.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK