Cao Y

AIMS: This study aims to develop and validate a Multi-Dimensional Computational Screening (MDCS) strategy to identify bioactive components by jointly considering target affinity, exposure potential, and safety, using Liangdi decoction (LDD)…

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by reproductive and metabolic abnormalities. This study aimed to identify key immunometabolic regulators in endometrial tissue and construct a …

Yaan Song,1– 5,* Yiqing Lin,1– 5,* Ming Yuan,1– 5 Ye Cao,1– 5 Guoyun Wang1– 5 1Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Medical Integra…

Endometriosis is a common gynecologic disorder that can be considered in two major categories based on whether the endometrium invades the myometrium: adenomyosis, in which the endometrial glands and mesenchyme migrate into the myometrium, …

OBJECTIVE: Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to explore the associ…

The modified cardiometabolic index (MCMI), an integrated measure of visceral fat and lipid metabolism, has been widely applied in metabolic disease research. However, its relationship with endometriosis has not been thoroughly investigated.…

This study aimed to improve the diagnosis and treatment of intramural pregnancy (IMP). A retrospective analysis was conducted of 8 cases of IMP admitted between November 2016 and June 2024. Data on patients' clinical characteristics, diagno…

BACKGROUND: Adenomyosis frequently coexists with other gynecological diseases, but the full spectrum of comorbidities and malignant conditions in surgically treated patients remain uncharacterized. This study sought to delineate concurrent …

BACKGROUND: Endometriosis (EMs) is a prevalent gynecological disorder among women of reproductive age. HAGLR has recently been identified as a potential factor in EMs, but its functional role and underlying mechanisms remain unclear. METHOD…

Endometriosis (EMs) features ectopic implantation of endometrial stromal cells (EESCs) and strong anoikis resistance, yet how inflammatory signals reprogram mitochondrial function remains unclear. Here, neutrophil extracellular traps (NETs)…

ObjectiveObesity impairs endometrial receptivity; however, the mechanism remains unclear. Obesity is associated with elevated leptin levels, and leptin receptor (Ob-Rb) has been demonstrated to be expressed in the human endometrium, but the…

IntroductionClimate change is increasing the frequency and severity of wildfires globally, leading to elevated air pollution and potential human health risks. This study examines whether large-scale wildfires impact indoor air quality withi…

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

Ovarian endometriosis (OvE) is a gynecological disorder with endometrial tissue in the ovaries, for which effective non-invasive diagnosis and curative treatments are currently lacking. Serum samples were collected from both discovery and v…

Age-related decreases in follicle numbers and oocyte quality are major contributors to the decline in female fertility, which is associated with increased infertility rates. Emerging evidence suggests that targeting granulosa cell senescenc…

Endometriosis is a chronic inflammatory disorder affecting approximately 10% of reproductive-age women, yet non-hormonal therapeutic options remain limited. This study investigates the role of the TLR4/NF-κB/NLRP3 inflammasome axis in endom…

Systemic inflammation and oxidative stress play key roles in female infertility. The red cell distribution width-to-albumin ratio (RAR) is a novel biomarker reflecting inflammation and nutritional status, but its association with female inf…

BackgroundAdverse birth outcomes are important public health measures and account for a substantial public health burden. There is considerable diversity of these health endpoints, as well as in the many factors suspected or recognized to i…

Long non-coding RNA Urothelial carcinoma-associated 1 (UCA1) is a pivotal regulator in the progression of endometriosis (EMs), yet its mechanistic role remains elusive. This study identified UCA1 as a factor promoting glycolysis through bio…

Study questionWhat is the incidence of triploidy and genome-wide uniparental disomy (gwUPD) in human embryos currently undetected by conventional preimplantation genetic testing (PGT)?Summary answerTriploidy and gwUPD were detected in 0.8% …

OBJECTIVE: To present an innovative approach of transumbilical single-port laparoscopic adenomyomectomy using the double-flap method combined with transient bilateral uterine artery occlusion, specifically for patients desiring uterine pres…

ObjectiveTo evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation.DesignMulticentre, double blind, placebo controlled, randomised clinical trial.Settin…

Adenomyosis is characterized by the invasion of endometrial glands and stroma into the myometrium. Its clinical manifestations often include dysmenorrhoea, excessive menstrual bleeding and infertility. Reduced pregnancy and live birth rates…

PurposeBladder cancer is one of the ten most common cancers in the world, with a high incidence rate and mortality, and therefore a major burden on the global health care system. PID1 (Phosphotyrosine Interaction Domain 1) functions as an i…

BackgroundThreatened abortion is a common obstetric complication where early risk stratification is crucial for clinical management. CA125, a glycoprotein biomarker produced by endometrial and trophoblastic tissues, may serve as a valuable …