Young Sik Choi

BACKGROUND: Adiposity influences reproductive function via endocrine and immune pathways. The association between body mass index (BMI) and anti-Müllerian hormone (AMH) in endometriosis is uncertain, and BMI may not fully capture adiposity-…

UNLABELLED: Endometriosis (EMS) is a chronic inflammatory disorder affecting ~10% of reproductive-age women, with increasing evidence implicating the microbiome in its pathogenesis through immunomodulation and estrogen metabolism. This stud…

Despite widespread rhFSH use in infertile women undergoing ART, real-world comparative data on its effectiveness and safety across different rhFSH types remain limited. Using the HIRA claims database, we included 10,684 women aged 20-39 wit…

Ovarian endometrioma cystectomy may compromise ovarian reserve through inadvertent excision of ovarian cortex. We compared inadvertent cortical removal between robotic-assisted and conventional laparoscopic cystectomy using digital patholog…

OBJECTIVE: This study aimed to investigate the effects of dienogest on depressive symptoms and anxiety in patients with endometriosis using the Center for Epidemiologic Studies Depression (CES-D) and State-Trait Anxiety Inventory (STAI). M…

Exposure to PM2.5 (particulate matter <2.5 μm) has been implicated in increasing the risk of endometriosis and worsening its symptoms. However, the molecular mechanisms and direct associations remain unclear. This study explored whether PM2…

OBJECTIVE: Exosomes are secreted by most cell types and reflect the internal state of their cells of origin, playing crucial roles in the progression of various pathological conditions. Endometriosis is a chronic, estrogen-dependent inflamm…

Background/Objectives: Oxidative stress is a critical factor in the development and progression of endometriosis. Granulosa cells, which reside near oocytes in follicles, exhibit steroidogenic activity, and, consequently, influence oocyte q…

Background/Objectives: Adenomyosis is characterized by aberrant endometrial invasion and heavy menstrual bleeding, with angiogenesis being implicated as a key mechanism of this condition. We compared vascular endothelial growth factor (VEGF…

OBJECTIVES: Formononetin is one of the phytoestrogens that functions like a selective estrogen receptor modulator (SERM). In this study, we evaluated the effects of formononetin on endometriosis progression in vitro and in vivo. MATERIALS …

ObjectiveThis study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET).Methods…

Cell membrane ion channels have important roles in cell migration during cancer development and metastasis. Although endometriosis is a benign gynecological disease, some migration and invasion characteristics of endometriosis are similar t…

OBJECTIVE: To investigate whether high-mobility group box-1 induces cell proliferation, invasion and mediates inflammation in ectopic human endometrial stromal cells through Toll-like receptor 4. METHODS: Ectopic endometrial specimens were…

PurposeThis study aimed to elucidate whether microRNA-139-5p is involved in the pathogenesis of uterine leiomyoma.Materials and methodsHuman leiomyoma and matched human smooth muscle samples were obtained from 10 women who underwent hystere…

The aim of this study was to determine predictive factors for pregnancy and assess the cumulative pregnancy rate (CPR) and live birth rate (CLBR) in subfertile couples undergoing timed intercourse (TI) using ultrasound. This retrospective c…

BackgroundThis study aimed to evaluate the compatibility of robotic single-site (RSS) myomectomy in comparison with the conventional robotic multi-port (RMP) myomectomy to achieve successful surgical outcomes with reliability and reproducib…

Endometriosis is a common gynecologic disorder characterized by chronic pelvic pain, dysmenorrhea, and infertility. Although this condition places significant financial burden on the healthcare system and negatively affects patient's qualit…

Objective: Endometriosis is a common gynecologic disorder that is characterized by chronic pelvic pain, dysmenorrhea, and infertility. Although the adverse effects of particulate matter on the human body and many diseases are proven, studie…

BackgroundDespite the good prognosis in patients with transplant organs, limited evidence is available on how immunosuppressants affect pregnancy. The aim of this study was to determine whether immunosuppressant use affects the pregnancy ou…

PROBLEM: Recently, interleukin (IL)-32 has been suggested to be involved in the pathogenesis of endometriosis. The aim of this study was to investigate whether serum IL-32 level might be used as a biomarker for diagnosis of endometriosis. …