Wang J

Extracellular matrix (ECM), once regarded as a passive structural scaffold, is now recognized as a key hallmark of aging. In the context of female reproductive aging, ECM remodeling acts as a pivotal driver of functional deterioration. This…

OBJECTIVES: To evaluate the feasibility of quantitative susceptibility mapping (QSM) and R2* mapping in assessing iron deposition in endometriotic ovarian cysts (EMO) and their potential implications for ovarian reserve. MATERIALS AND METH…

PurposeThe growing antimicrobial resistance in Neisseria gonorrhoeae (N. gonorrhoeae) complicates the elimination of gonococcal infections and increases the risk of female infertility. In this study, we investigated the antimicrobial suscep…

ObjectiveTo evaluate the association between prior mode of delivery (cesarean vs. vaginal) and endometrial thickness in the subsequent frozen embryo transfer (FET) cycle. The secondary aim was to evaluate FET cycle outcomes.DesignRetrospect…

PURPOSE: Observational studies have indicated a potential link between adenomyosis/endometriosis and adverse pregnancy outcomes (APOs), yet the potential relationship remains uncertain. PATIENTS AND METHODS: This study investigates whether…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, with prognosis limited by extensive resistance to platinum-based therapy. Although the pregnane X receptor (PXR) has been implicated in chemoresistance, the u…

ObjectiveThis study aims to investigate the role and regulatory mechanisms of PTP1B in acute pancreatitis.MethodsAn in vitro AP cell model was established using Caerulin (CAE). Cells were subsequently treated with MSI-1436 (PTP1B inhibitor)…

Endometriosis, a prevalent gynecological disease affecting women's health, involves altered immune function. This study investigates the immune checkpoint protein, V-domain immunoglobulin suppressor of T cell activation (VISTA) as a therape…

BackgroundPreeclampsia is a severe hypertensive disorder with rising global prevalence. While machine learning (ML) models for predicting preeclampsia are increasingly published, existing evidence shows high heterogeneity, and the distincti…

Endometriosis (EMs) is a prevalent gynecological disorder affecting reproductive-age women. Exosomes secreted by peripheral blood macrophages may participate in EMs progression. In this pilot translational study, exosomes from peripheral bl…

The clinical management of endometriosis encounters a significant obstacle: existing therapies inadequately address both the inhibition of ectopic lesion proliferation and the mitigation of the neuroinflammation associated with chronic pain…

This study explores how quercetin may treat endometriosis (EMs) by combining network pharmacology and transcriptome sequencing approaches. Through network pharmacology, 132 shared targets between quercetin and EMs were identified, with KEGG…

OBJECTIVE: This review comprehensively explores the potential relationship between the microbiota and adenomyosis, aiming to identify specific microbial biomarkers, elucidate the molecular mechanisms underlying the involvement of the microb…

For women with diminished ovarian reserve or of advanced age, controlled ovarian stimulation presents a significant challenge during in vitro fertilization cycles. This multi-center, open-label, randomized controlled trial enrolled 318 wome…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease often treated with blood-activating and stasis-resolving therapies. Anxiety and depression are common mental comorbidities in patients with EMs. There are no medications avai…

Endometriosis (EMS) remains understudied in effective management strategies. The interplay between macrophage dysfunction and microbiota-derived immune signals emerges as a potential mechanism in EMS pathogenesis, suggesting its relevance f…

Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs…

BackgroundHyperthyroidism adversely impacts female reproduction, yet its association with in vitro fertilization (IVF) outcomes remains controversial. It remains unknown whether ovarian function recovers upon achieving euthyroidism. We comp…

ObjectivesThe objective of this study was to evaluate the safety and efficacy of intratumoral ethanol injection followed by high-intensity focused ultrasound (HIFU) for hyperintense uterine fibroids on T2-weighted magnetic resonance images …

Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee…

BACKGROUND: Endometriosis (EM) is a disease related to reproductive dysfunction. The mechanism of epigenetic factors (EF) in EM still needs to be studied. Emerging evidence suggests that EF plays a role in the development of EM. However, th…

Ovarian cancer (OC) is a leading cause of gynecologic cancer mortality, with survival prediction limited by existing prognostic models that fail to capture tumor heterogeneity. Conventional methods lack precision for individualized risk ass…

Neurogenic bladder (NB)-induced fibrosis is the major cause of irreversible bladder dysfunction, yet the underlying mechanisms remain undefined. Here, leveraging single-cell RNA sequencing, the fibrotic landscape of NB is delineated and a d…

Endometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometri…