Frontiers in oncology

BackgroundUterine adenosarcoma is a rare malignant tumor characterized by a biphasic pattern consisting of benign epithelial components and sarcomatous stroma. The subtype with sarcomatous overgrowth is more aggressive and poses significant…

ObjectiveThis study aimed to develop an ultrasound-based deep learning radiomics nomogram for differentiating endometrial hyperplasia with polyps from endometrial cancer in endometrial lesions and to explore its clinical diagnostic efficacy…

Tumor heterogeneity is a core challenge in gynecologic oncology, driving therapeutic resistance and limiting the efficacy of single-point biopsies. Artificial intelligence (AI) and radiomics are emerging as a "digital biopsy" to non-invasiv…

BackgroundEpidemiologic evidence on the association between infertility and thyroid cancer risk remains inconsistent. We conducted a systematic review and meta-analysis to synthesize available observational evidence and quantify this associ…

ObjectiveTo evaluate the association between hormone therapy and the development, progression, and treatment response of spheno-orbital meningiomas (SOMs) and to identify current evidence gaps in clinical management.MethodsA systematic lite…

BackgroundPelvic floor dysfunction (PFD) is a common functional disorder following total hysterectomy. Currently, the assessment mainly relies on manual measurements of transperineal ultrasound (TPUS) images, which suffers from low efficien…

Current anti-angiogenic therapies using vascular endothelial growth factor-A/vascular endothelial growth factor receptor-2 (VEGF-A/VEGFR2) inhibitors lack dynamic biomarkers that can facilitate patient selection and optimize dosing; this ca…

IntroductionSerous surface papillary borderline ovarian tumors (SSPBOTs), a clinically distinct variant of serous borderline ovarian tumors (SBOTs), are frequently misdiagnosed as malignant tumors during preoperative diagnostic assessments.…

BackgroundCases of primary clear cell adenocarcinoma of the vagina (PCCAV) are infrequently encountered and account for only 5%-10% of all primary vaginal cancers 1. The most common associated risk factor for developing PCCAV is in utero ex…

Uterine leiomyoma is a common benign tumor of the uterus and typically demonstrates low FDG uptake on 18F-FDG PET/CT. Intense FDG uptake in a uterine mass is generally considered suggestive of malignancy. Here, we report a case of uterine l…

BackgroundFumarate hydratase (FH)-deficient uterine leiomyoma is a rare pathologic marker for hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Its recognition is crucial for initiating life-saving surveillance.Case prese…

ObjectiveTo present two cases of primary ovarian squamous-cell carcinoma (POSCC) and describe a comprehensive review and analysis of the published related literature.MethodsWe reviewed the medical records of two patients with POSCC who unde…

BACKGROUND: Large-cell neuroendocrine carcinoma (LCNEC) of the female genital tract is rare and highly aggressive. When the dominant tumor burden is intramyometrial, preoperative imaging may mimic benign myometrial disease and delay oncolog…

Deep infiltrating endometriosis (DIE) is a severe form of endometriosis that rarely undergoes malignant transformation, and when it does, diagnosis is often difficult. Here, we report two cases of long-standing DIE that progressed to endome…

Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10 ye…

[This corrects the article DOI: 10.3389/fonc.2022.859510.].

Pelvic ectopic kidney is a rare congenital anomaly, occurring in approximately 0.1% of the adult population, and is often asymptomatic. However, it can easily be mistaken for a pelvic tumor or lymph-node metastasis. This case report details…

IntroductionEpithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, and accurate prediction of long-term survival remains challenging. This study aimed to evaluate the prognostic associations of prespecified clinic…

BackgroundsThe preoperative differentiation of borderline ovarian epithelial tumors (BOETs) remains challenging. While systemic inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and m…

IntroductionEndometrial cancer has the highest incidence among gynecologic malignancies, with a global prevalence of 10-20%. Type II tumors are generally high-grade and recurrent. Combination chemotherapy can provide synergistic effects to …

Ovarian cancer is the deadliest gynecologic cancer in individuals assigned female at birth. Patients diagnosed with ovarian cancer experience poor survival rates due to frequent late-stage diagnosis and aggressive metastases. Ovarian cancer…

BACKGROUND: Endometriosis is common in reproductive-age women, but the development of an endometriotic cyst that mimics tumor recurrence during follow-up after treatment for ovarian immature teratoma poses a significant diagnostic challenge…

Intravascular papillary endothelial hyperplasia (IPEH) is a rare vascular lesion that can histologically mimic malignant vascular tumors, particularly angiosarcoma, often leading to misdiagnosis and overtreatment. IPEH involving the uterine…

BACKGROUND: Endometriosis is a prevalent benign condition among women of reproductive age. While the overall rate of endometriosis-associated malignancy is low, the risk of malignant transformation increases significantly in postmenopausal …

INTRODUCTION: We report an unexpected case of mesonephric-like adenocarcinoma initially treated as a diffuse adenomyosis in a patient presenting with primary infertility. The aim of this report is to raise clinical awareness about the risk …