Milena Králíčková

Endometriosis is a complex and chronic estrogen-dependent disease, affecting a significant proportion of women of reproductive age. Despite the long interest and extensive research, the pathogenesis of the disease is still debated. Although…

PurposeDespite long and intensive research, endometriosis remains one of the leading causes of morbidity among premenopausal women. The majority of endometriosis-related ovarian carcinomas occur in the presence of atypical ovarian endometri…

BACKGROUND: This study was conducted to summarize current knowledge of the changes within the immune system, from action of macrophages, lymphocytes and NK cells to biological effects of their products. Endometriosis is a complex gynecologi…

Endometriosis is a serious health problem characterized by the persistence and growth of vascularized tissue at various ectopic sites such as ovaries, bowel, or bladder. Despite decades of intensive research, we are not making significant p…

Introduction Endometriosis usually defined as the presence of endometriallike tissue outside the uterus, is a condition affecting about 10% of the population of women in reproductive age. Whereas the effects on overall health conditions and…

Numerous studies are seeking noninvasive methods to diagnose endometriosis, but a clinically applicable test is still missing. Current paper compares the current results in our search for the best diagnostic marker. We summarize that despit…

PurposeEndometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. This may provoke a breakdown in the per…

Introduction Endometriosis is chronic inflammatory disease characterized by implantation and subsequent proliferation of endometrial tissue outside the uterine cavity. Etiology and pathogenesis of this disease remain unclear despite decades…

Endometriosis is a benign, but serious gynecologic condition affecting millions of women. This disease is defined by the presence of endometrial tissue outside the uterus. Despite decades of intensive research, the mechanisms of endometrios…

Endometriosis is a benign, but serious gynecologic condition affecting millions of women. This disease is defined by the presence of endometrial tissue outside the uterus. Despite decades of intensive research, the mechanisms of endometrios…

Endometriosis is a common and serious illness affecting women in their reproductive years. Despite the ongoing interest and intensive research of this crippling disease, the cause remains unknown since its first description over 150 years a…

Endometriosis is manifested by the presence of both endometrial glandular and stromal cells outside the uterine cavity. It is characterized by ectopic implantation of endometrial cells with elevated proliferation and migration. Endometriosi…

Endometriosis is the leading cause of morbidity among premenopausal women and the complex pathogenesis of this disease remains controversial despite extensive research. This disease represents one of the most common gynecological problems. …

Objectives Current findings in the biology of tumors and also new tools for genome analysis have opened clinical perspectives in oncology, generally termed as ‘personalized medicine’. Pharmacogenomics examines how the benefits and adverse e…

The frequency of functionally relevant mutations of the leukaemia inhibitory factor (LIF) gene in infertile women is significantly enhanced in comparison with fertile controls. The objective of this retrospective cohort study was to evaluat…

To characterize the impact of the potentially functional mutation--the G to A transition at the position 3400 of the leukemia inhibitory factor (LIF; a pluripotent cytokine that plays a central role in the control of the embryo implantation…