Eric J. Thomas

The recent ability to diagnose asymptomatic endometriosis has produced dilemmas, particularly with respect to the need for treatment. The first placebo-controlled study of drug treatment in asymptomatic endometriosis shows that although spo…

It is well known that certain aspects of endometriosis are similar to those of malignant disease. For example, like cancer, endometriosis can be both locally and distantly metastatic; it attaches to other tissues, invades, and damages them.…

In a series of studies, we have hypothesised that endometriotic proliferation is, in part, precipitated by mutations in oncogenes or deletions in tumor suppressor genes that have been shown to be important steps in the transformation from a…

Clinicians have a number of unmet needs regarding the diagnosis and management of endometriosis. The fulfilment of these would result in better advice for patients.

Endometriosis is a common gynecological disease in which tissue similar to the endometrium proliferates at sites outside the uterine cavity. Malignant transformation of endometriosis to endometrioid and clear cell ovarian carcinomas has bee…

Impaired galactose metabolism has been proposed as a risk factor for ovarian cancer and endometriosis, which is a putative precursor of endometrioid and clear cell histological sub-types of ovarian cancer. The prevalence of the most common …

Impaired galactose metabolism has been proposed as a risk factor for ovarian cancer and endometriosis, which is a putative precursor of endometrioid and clear cell histological sub-types of ovarian cancer. The prevalence of the most common …

Abstract Endometriosis is defined as the presence of endometrium-like glands and stroma outside the uterine cavity and myometrium. Adenomyosis, where such tissue is present within the myometrium, is reviewed in Chapter 24. Current opinion r…

Endometriosis is a very common gynecological condition in which tissue similar to endometrium proliferates at sites outside the uterine cavity, most commonly the ovary. Although it generally remains a benign condition, malignant transformat…

Granulosa cells were isolated from follicular aspirates collected at ovum recovery for in vitro fertilization. Cells were cultured in a defined medium on artificial extracellular matrix (Matrigel) in the presence or absence of hCG as a mode…

OBJECTIVE: To compare the expression of cell adhesion molecules by endometrium and endometriosis. DESIGN: A comparative study of integrin expression, determined immunohistochemically, in eutopic and ectopic endometrium biopsied synchronousl…

This study investigated the development of functional ovarian cysts during pituitary down-regulation prior to in-vitro fertilization (IVF), and identified 16 cases of cysts in 288 IVF cycles studied. Comparing the patients with functional o…

encourage more people to take an overdose.It should, however, reduce the likelihood of an accidental overdose being taken from severe pain and increase the chance that if a patient's family knows of the overdose they will encourage him or h…

Growth factors play a role in the cyclical growth and vascularization of normal endometrium. Abnormal endometrial proliferation and neovascularization may result in endometriosis. This study determines the presence and localization of acidi…

(1992). Endometriosis Chairman's summary. Journal of Obstetrics and Gynaecology: Vol. 12, No. sup2, pp. S45-S45.

OBJECTIVE: To study epidermal growth factor (EGF) receptor expression in endometrium throughout the menstrual cycle and to compare EGF-receptor expression in endometrium from patients with endometriosis with receptor expression in synchrono…

Endometriosis is an oestrogen dependent condition and it is expected that the tissue of origin of endometriosis will express receptors for the ovarian steroids. Two epithelia, endometrium and peritoneal mesothelium, are the potential parent…