J. Donnez

Study Objective: To estimate the effect of combined oral contraceptives (COCs) in women with deep infiltrating endometriosis (DIE).Design: Retrospective study (Canadian Task Force classification II-2).Setting: Tertiary care university hospi…

BackgroundUreter injuries are the most dreaded complication in gynaecological surgery.Some risk factors for the occurrence of urinary tract injuries are known, but clear guidelines to prevent ureter injuries during laparoscopic hysterectomy…

Chapter 1 1.1 Chapter 1 13.2.2Ce// actf?es/on mo/eci//es Adhesive properties of endometrial cells determine the process of attachment of retrogradely shed endometrium to the peritoneal lining.Several cell adhesion molecules are expressed by…

Abstract Study question Do endometrial assembloids derived from eutopic endometrium from endometriosis and adenomyosis patients exhibit altered molecular and functional responses to progesterone compared with healthy controls? Summary answe…

Abstract Study question Our goal was to determine whether the administration of temsirolimus and recombinant AMH, concomitant with chemotherapy, is effective in protecting fertility from chemotherapy-induced damage. Summary answer The admin…

Adenomyosis is a benign invasion of endometrial glands and stroma into the uterine myometrium. [1, 2]. It can present with heavy and painful menstrual bleeding or be asymptomatic [2-4]. Over last three decades the diagnosis of adenomyosis h…

STUDY QUESTION: Which biological mechanisms are responsible for physiological ovarian reserve decline owing to aging, or pathological follicle depletion triggered by inflammation or a pro-oxidant environment throughout a woman's lifetime? …

Endometriosis is a common problem affecting 5-10% of women of childbearing age. It is a condition with unknown pathology, leaving us with several theories. However, about half of women with endometriosis complain of difficulty conceiving. T…

Abstract Endometriosis is a benign estrogen-dependent disease In the ovary, endometrioma formation may cause local inflammation, giving rise to structural alterations to the ovarian cortexwhich manifest as massive fibrosis and loss of corte…

Abstract Study question Is once-daily linzagolix treatment for women with moderate to severe endometriosis-associated pain (EAP) safe for use for up to 6 months of treatment? Summary answer Both doses of linzagolix were well-tolerated with …

BACKGROUND: Without an adequate animal model permitting experiments the pathophysiology of endometriosis remains unclear and without a non-invasive diagnosis, information is limited to symptomatic women. Lesions are macroscopically and bioc…

Endometriosis is an inflammatory condition characterised by existence of endometrial tissue in extra uterine locations, being aggressive and invasive can cause a significant decrease in quality of life. Various scientific evidence suggests …

Endometriosis is defined as the presence of endometrium outside of uterine cavity and thought to develop through reverse menstruation of endometrial tissue into the peritoneal cavity. Endometrial cell implantation into peritoneal cavity is …

Background. Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification …

High Doppler resistive indices in a hemorrhagic corpus luteum suggest a possible an eventful transformation to endometrioma.

'To whom correspondence should be addressed A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed i…

'To whom correspondence should be addressed A computerized morphometrical investigation was per-formed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologicall…

PURPOSE: To assess the safety of reimplantation of cryopreserved ovarian tissue from advanced-stage breast cancer patients. METHODS: Cryopreserved ovarian cortical fragments were obtained from 13 advanced-stage breast cancer patients aged …

Sampson's menstrual reflux theory is commonly used to explain the origin of endometriotic lesions in women. However, their pathogenesis remains largely unknown. Validated research models need to be developed with the aim of studying mechani…

BACKGROUND: Steroid sulfatase (STS) is involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of disease-free and endometriosis patients. The present study was designed to investigate its role in endometriosis de…

To study the effect of endometriosis on follicular rupture, endometrial tissue was autografted to New Zealand White rabbits. Endometrium was surgically implanted into the peritoneal cavity or into the rectus muscle. Human chorionic gonadotr…

Data on the presence of an ovulation ostium and the volume and the concentrations of estradiol (17 beta-estradiol) and progesterone In women with endometriosis (n = 80) and women with luteinized unruptured follicle (LUF) syndrome (n = 32) a…

BACKGROUND: Aromatase has been reported to be involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of endometriosis patients. The objective of the present study was to investigate its expression and localizatio…