Endometrial stromal sarcoma arising from endometriosis of the terminal ileum: the role of immunohistochemistry in the differential diagnosis

Ioannis Biliatis, Akrivos N, Nikolaos Akrivos, Sotiropoulou M, Maria Sotiropoulou, Alexandros Rodolakis, Rodolakis A, Maria Simou, Simou M, Antsaklis A, Aris Antsaklis
Journal of Obstetrics and Gynaecology Research · 2012 · vol. 38(5) , pp. 899–902 · doi:10.1111/j.1447-0756.2011.01783.x · PMID:22413936 · W1505720383
Case report OA: closed CC0 ⤵ 7 in-corpus citations
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This case report details a rare instance of low-grade endometrial stromal sarcoma arising from ectopic endometriosis in the terminal ileum, highlighting the crucial role of immunohistochemistry in its diagnosis.

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Abstract

Low-grade endometrial stromal sarcoma (LESS) is an uncommon uterine malignancy. Occasionally, it may develop in extrauterine endometriotic lesions and present morphological characteristics mimicking various neoplasms, making its diagnosis very challenging. We report a rare case of a 56-year-old woman presenting with a pelvic mass, initially presumed to be of ovarian origin. After surgical excision the diagnosis of a LESS arising from foci of endometriosis of the terminal ileum was established. Pelvic lymph nodes and omentum were also infiltrated. The patient received adjuvant chemotherapy and medroxyprogesterone; she is alive with no evidence of disease after a follow-up of 38 months. Immunohistochemical characteristics of the tumor are very important for the differential diagnosis of this rare neoplasm and include diffuse strong positivity for CD 10, estrogen receptor expression and CD 34 negativity.

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Condition tags

endometriosis

MeSH descriptors

Endometrial Neoplasms Endometriosis Ileal Diseases Sarcoma, Endometrial Stromal Antigens, CD34 Antigens, CD34 Antigens, CD34 Diagnosis, Differential Diagnosis, Differential Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (9)

Cited by (7)

Source provenance

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