Microvascular density in conditions of endometrial atrophy
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⤵ 11 in-corpus citations
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This study found that microvascular density in the endometrium of postmenopausal women and those treated with danazol or goserelin did not significantly differ from control populations.
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Abstract
Irregular menstrual bleeding in users of hormonal contraception represents the single major reason for discontinuation of these contraceptive methods. The mechanisms which underlie these bleeding disturbances are poorly understood, but appear to be associated with changes in the endometrial microvasculature following abnormal patterns of sex steroid exposure. Endometrial microvascular density is known to be increased in users of the low-dose levonorgestrel contraceptive implant, Norplant. This study explores microvascular density in other conditions of spontaneous (post-menopausal) and induced (danazol and goserelin) endometrial atrophy. Endometrial biopsies were fixed, paraffin-embedded and sections were immunostained using anti-CD34 antibody to identify vascular endothelial cells. The mean microvascular density (+/-SEM) for control samples was 186 +/- 8 vessels/mm2. There were no statistically significant changes in vascular density observed across the menstrual cycle. Mean microvascular density in spontaneous and induced endometrial atrophy did not differ significantly from that observed in the control population. The mean microvascular density was 230 +/- 17 vessels/mm2 in 31 postmenopausal women, 269 +/- 67 vessels/mm2 in 25 subjects treated with danazol was and 191 +/- 45 vessels/mm2 in nine subjects treated with goserelin. These findings suggest that the mechanisms controlling microvascular density in conditions of endometrial atrophy may vary according to the nature of the atrophic stimulus.
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References (13)
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Cited by (11)
- Aging of the endometrium 2008
- Influence of different hormonal regimens on endometrial microvascular density and VEGF expression in women suffering from breakthrough bleeding 2005
- Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model 2005
- Influence of different hormonal regimens on endometrial microvascular density and VEGF expression in women suffering from breakthrough bleeding 2005
- Impact of different progestins on endometrial vascularisation of postmenopausal women. A retrospective image analysis-morphometric study 2003
- Comparative endometrial histology in postmenopausal women with sequential hormone replacement therapy of estradiol and, either chlormadinone acetate or micronized progesterone 2002
- Disturbances of endometrial bleeding with hormone replacement therapy 2000
- The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium 2000
- A longitudinal study of changes in endometrial microvascular density in Norplant implant users 1999
- The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium 1999
- Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis 1998
Source provenance
- openalex
- last seen: 2026-05-11T05:54:30.111693+00:00
- pubmed
- last seen: 2026-10-08T22:00:02.201502+00:00
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