The Secondary Müllerian System Revisited
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⤵ 28 in-corpus citations
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This paper proposes that peritoneal proliferations of secondary müllerian epithelium, including endometriosis and ovarian cancers, may be initiated by talc exposure during infancy, suggesting reduced incidence with starch powder and ovulation suppressants.
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Abstract
The peritoneum is the matrix where benign and malignant proliferation of secondary müllerian epithelium occur. Endometriosis, endosalpingiosis, and endocervicosis are benign peritoneal neoplasms corresponding to endometrioid, serous, and mucinous carcinomas. These latter are concentrated predominantly, although not exclusively in the ovary, and reasons for this localization are discussed. Exposure to talc, or perhaps to the asbestos that often contaminates it, occurs in the process of powdering during infancy and may be the major initiating factor in benign and malignant disorders of the secondary müllerian system. It can be anticipated that the incidence both of endometriosis and of ovarian tumors will be reduced in those women powdered with starch instead of talc during infancy, as well as by the continued use of ovulation-suppressing agents such as contraceptive steroids.
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Cited by (28)
- Enhanced peroperative imaging of endometriosis and peritoneal carcinomatosis 2024
- Primary Retroperitoneal Carcinomas: New Insights into Pathogenesis and Clinical Management in Comparison with Ovarian Carcinomas and Carcinoma of Unknown Primary 2023
- Low-grade extrauterine endometrial stromal sarcoma of the peritoneum: A case report and literature review 2020
- Low-grade extrauterine endometrial stromal sarcoma of the peritoneum: A case report and literature review 2020
- Two resected cases of Mullerian cyst in the posterior mediastinum 2018
- Primary low-grade endometrial stromal sarcoma arising in the vagina: report of an unusual case and literature review 2017
- Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis 2017
- Tubal origin of ovarian endometriosis and clear cell and endometrioid carcinoma. 2015
- Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas 2015
- Evidence for lymphatic pathogenesis of endosalpingiosis: the more things change, the more they stay the same 2015
- Pathological Aspect and Pathogenesis of Endometriosis 2014
- Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature 2014
- Primary retroperitoneal Müllerian adenocarcinoma arising from endometriosis 2014
- Secondary Mullerian System 2013
- Pathological Aspects of Endometriosis 2012
- Tumors and Pseudotumors of the Secondary Müllerian System: Review With Emphasis on Cross-Sectional Imaging Findings 2010
- Pathogenesis of endometriosis 2010
- Endometrial metaplasias and reactive changes: a spectrum of altered differentiation 2010
- Endometriosis 2009
- Morphological variations of scar-related and spontaneous endometriosis of the skin and superficial soft tissue: A study of 71 cases with emphasis on atypical features and types of müllerian differentiations 2007
- Primary ovarian adenocarcinoma developing in ovarian remnant tissue ten years after laparoscopic hysterectomy and bilateral salpingo-oophorectomy for endometriosis 2007
- Low-grade endometrial stromal sarcoma presenting as vaginal nodule 2004
- Endometriosis and ovarian cancer: Thoughts on shared pathophysiology 2003
- X. Dr. Robert Meyer 2001
- Immunohistochemical analysis of CA125, CA19–9, and Ki-67 in stage III or IV endometriosis: positive correlation between serum CA125 level and endometriotic epithelial cell proliferation 2000
- The importance of histological diagnosis in patients with chronic pelvic pain and laparoscopic evidence of endometriosis 2000
- Chapter 4 What is Endometriosis? 1999
- Benign and Malignant Serous and Endometrioid Epithelium in the Omentum 1999
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- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:11:29.222973+00:00
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