Pathological Aspect and Pathogenesis of Endometriosis

Historically, endometriosis was first described in Egyptian scrolls in the sixteenth century bc. The first scientific description of endometriosis was published by Carl Freiherr von Rokitansky in 1860. At this time, the concept of endometriosis as a disease entity was not established and it was assumed to be an enigmatic disease with an unknown pathology. Although extensive basic and clinical research has been carried from the last century until present, the pathogenesis of endometriosis is still controversial. Major theories on the pathogenesis of endometriosis are (1) metastases of endometrial tissues to an ectopic location (transplantation theory), (2) metaplastic development of endometrial tissue on the ectopic site (metaplastic theory), and (3) changes of the embryonic duct remnant epithelium into endometrial epithelium (müllerian remnants theory). A comprehensive understanding of the histopathogenesis of endometriosis is essential to the novel clinical approaches for the enigmatic disease. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

von Rokitansky C. Ueber Uterusdrusen-Neubilding in Uterus- und Ovarial – Sarcomen. Ztschr KK Gesellsch Der Aerzte zu Wien. 1860;37:577–81. Cullen TS. Adeno-myoma uteri diffusum benignum. Johns Hopkins Hosp Bull. 1896;6:133–7. Sampson JA. Perforating hemorrhagic cysts of the ovary. Their importance and especially their relation to adenomas of the endometrial type. Arch Surg. 1921;3:245–323. Sampson JA. Inguinal endometriosis. Am J Obstet Gynecol. 1925;10:462–503. Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69. Olive DL, Pritts EA. Treatment of endometriosis. N Engl J Med. 2001;345:266–75. Suginami H. A reappraisal of the coelomic metaplasia theory by reviewing endometriosis occurring in unusual sites and instances. Am J Obstet Gynecol. 1991;165:214–8. Lauchlan SC. The secondary müllerian system. Obstet Gynecol Surv. 1972;27:133–46. Clement PB. Reactive tumor-like lesions of the peritoneum. Am J Clin Pathol. 1995;103:673–6. Lauchlan SC. The secondary Müllerian system revisited. Int J Gynecol Pathol. 1994;13:73–9. Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H. Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol. 2002;83:149–55. Okamura H, Katabuchi H. Pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesis. Int Rev Cytol. 2005;242:1–54. Ridley JH. Pathogenesis of endometriosis. A review of facts and fancies. Obstet Gynecol Surv. 1968;23:1–35. Victory R, Diamond MP, Johns DA. Villar’s node: a case report and systematic review of endometriosis externa of the umbilicous. J Mnim Invasive Gynecol. 2007;14:23–33. Katabuchi H. J Japan Societ Endo. 2009. Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64:151–4. Okamura H, Katabuchi H. Detailed morphology of human ovarian surface epithelium focusing on its metaplastic and neoplastic capability. Ital J Anat Embryol. 2001;106:263–76. Nakamura M, Katabuchi H, Ohba T, Fukumatsu Y, Okamura H. Isolation, growth and characteristics of human ovarian surface epithelium. Virchows Arch. 1994;424:59–67. Ohtake H, Katabuchi H, Matsuura K, Okamura H. A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels. Fertil Steril. 1999;71:50–5. Okamura H, Katabuchi H, Nitta M, Ohtake H. Structural changes and cell properties of human ovarian surface epithelium in ovarian pathophysiology. Microsc Res Tech. 2006;69:469–81. Zeitoun K, Takayama K, Sasano H, Suzuki T, Moghrabi N, Andersson S, Johns A, Meng L, Putman M, Carr B, Bulun SE. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab. 1998;83:4474–80. Bulun SE, Cheng YH, Yin P, Imir G, Utsunomiya H, Attae E, Innes J, Julie KJ. Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol. 2006;248:94–103. Attia GR, Zeitoun K, Edward D, Johns A, Carr BR, Bulun SE. Progesterone receptor isoform A but not B is expressed in endometriosis. J Clin Endocrinol Metab. 2000;85:2897–902. Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, Lessey BA, Giudice LC. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007;148:3814–26. Jones RK, Searle RF, Bulmer JN. Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. Hum Reprod. 1998;13:3496–502. Treloar SA, Wicks J, Nyholt DR, Montgomery GW, Bahlo M, Smith V, Dawson G, Mackay IJ, Weeks DE, Bennett ST, Carey A, Ewen-White KR, Duffy DL, O’Connor DT, Barlow DH, Martin NG, Kennedy SH. Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26. Am J Hum Genet. 2005;77:365–76. Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Lambert A, Zhao ZZ, Roseman F, Guo Q, Gordon SD, Wallace L, Henders AK, Visscher PM, Kraft P, Martin NG, Morris AP, Treloar SA, Kennedy SH, Missmer SA, Montgomery GW, Zondervan KT. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43:51–4. Fukumatsu Y, Katabuchi H, Miyamura S, Matsuura K, Okamura H, Naito M, Takahashi K. Activated macrophages in the peritoneal fluid of women with endometriosis: examination of the intracytoplasmic localization of endogenous peroxidase and interleukin-1. Acta Obst Gynaec Jpn. 1992;44:529–36. Okamura H, Katabuchi H, Kanzaki H. Macrophages in reproductive biology. In: Lewis C, Burke B, editors. The Macrophages. London: Oxford University Press; 2002. p. 548–76. Sharpe-Timms KL, Piva M, Ricke EA, Surewicz K, Zhang YL, Zimmmer RL. Endometriotic lesions synthesize and secrete a haptoglobin-like protein. Biol Reprod. 1998;58:988–94. Co-workers in our Department Okamura H, Matsuura K, Ohba T, Tashiro H, Fukumatsu Y, Nakamura M, Ohtake H, Motohara K, Miyamura S. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2014 Springer Japan About this chapter Cite this chapter Honda, R., Katabuchi, H. (2014). Pathological Aspect and Pathogenesis of Endometriosis. In: Harada, T. (eds) Endometriosis. 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