Abnormal activation of the sonic hedgehog signaling pathway in endometriosis and its diagnostic potency

He Y, Yanan He, Qiuyan Guo, Guo Q, Cheng Y, Yan Cheng, Qu Y, Yanjun Qu, Sun L, Liyuan Sun, Congcong Kong, Kong C, Liang Lei, Lei L, Lei Liang, Guangmei Zhang, Zhang G
Fertility and sterility · 2018 · vol. 110(1) , pp. 128–136.e2 · doi:10.1016/j.fertnstert.2018.02.138 · PMID:29980254 · W2810272200
article OA: bronze CC0 ⤵ 13 in-corpus citations
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This study found upregulated sonic hedgehog (SHH) signaling molecules in the eutopic endometrium of endometriosis patients, suggesting diagnostic potential for the SHH pathway.

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Abstract

ObjectiveTo investigate the abnormal expression of sonic hedgehog (SHH) signaling molecules in 52 eutopic endometrial tissues and its diagnostic potency in endometriosis.DesignRetrospective study.SettingUniversity hospital.Patient(s)Twenty-six women with histologically confirmed endometriosis and 26 women with histologically normal endometria who were undergoing curettage or hysterectomy were selected.Intervention(s)None.Main outcome measure(s)The mRNA and protein levels of molecules in the SHH signaling pathway.Result(s)The levels of SHH, smoothened, GLI family zinc finger 3, and its downstream signaling transcription factor (GLI1) not only were upregulated in the eutopic endometrium of endometriosis compared with the control endometrium, but also independently predicted the onset and severity of the disease.Conclusion(s)This study is the first to reveal differences in the activation of the SHH signaling pathway between women with and without endometriosis and suggests that the SHH signaling pathway has potential in the diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hedgehog Proteins Nerve Tissue Proteins Signal Transduction Smoothened Receptor Zinc Finger Protein GLI1 Zinc Finger Protein Gli3 Adult Biomarkers Biomarkers Biopsy Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Hedgehog Proteins

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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