Endogenous prostaglandins in dysmenorrhea and the effect of prostaglandin synthetase inhibitors (PGSI) on uterine contractility

V. Lundström, K Gréen, Krister Gréen, Kerstin Svanborg, K Svanborg
Acta obstetricia et gynecologica Scandinavica. Supplement · 1979 · vol. 58(S87) , pp. 51–56 · doi:10.3109/00016347909157790 · PMID:111466 · W1979414306
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Dysmenorrheic women exhibit elevated prostaglandin F2 alpha levels in plasma and endometrium, with prostaglandin synthetase inhibitors effectively reducing uterine contractility and symptoms.

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Abstract

The plasma concentration of 13,14-dihydro-PGF2 alpha during menstruation were determined by gas chromatography in 6 non-dysmenorrheic and 10 dysmenorrheic women. Nine out of 10 dysmenorrheic women were found to have increased levels (greater than 50 pg/ml) of the metabolite compared with mean level 25 pg/ml for non-dysmenorrheic women. All 9 women with elevated PGF2 alpha-metabolite levels responded favourably to treatment of dysmenorrhea with prostaglandin synthetase inhibitors. Determinations of PGF2 alpha in the endometrium carried out by gas chromatography-mass spectrometry showed 4 times higher concentrations in 5 dysmenorrheic women compared with 5 non-dysmenorrheic subjects. Treatment of dysmenorrhea with placebo or naproxen 250 mg and 500 mg in 6 patients resulted in decrease in tonus and amplitude of the contractions with a more rapid effect following administration of naproxen 500 mg while no effect was seen in 5 out of 6 patients following administration of placebo.

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Condition tags

dysmenorrhea

MeSH descriptors

Cyclooxygenase Inhibitors Dysmenorrhea Indomethacin Naproxen Prostaglandins F Uterine Contraction Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometrium Endometrium Female Humans Indomethacin Menstruation Muscle Tonus Muscle Tonus Naproxen Placebos Prostaglandins F

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