The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrheic patients
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Naproxen-sodium was investigated for its impact on intrauterine pressure and menstrual pain experienced by patients suffering from dysmenorrhea.
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Abstract
The Prostaglandin-synthesis inhibitor: Naproxen-Sodium (NS) (an analgesic agent) very significantly (P less than 0.001) reduced the "resting" and "active" pressures and the frequency of cyclic uterine activity of 10 dysmenorrheic patients. It also highly significantly reduced (P less than 0.001) menstrual pain. Since these effects were observed after a single oral dose of 1100 mg NS, without side effects or complications, extensive field trials are recommended for assessing therapeutic benefits of this treatment.
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Cited by (28)
- Painful menstruation 2005
- The effect of nimesulide and naproxen on the uterine and ovarian arterial blood flow velocity. A Doppler study 1995
- Prostaglandins in Dysmenorrhoea and Endometriosis 1992
- Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol 1991
- Human menstruation and eicosanoids 1990
- Dysmenorrhö und Leistungssport 1988
- The Effect Of Flurbiprofen And Naproxen Sodium On Intra‐Uterine Pressure And Menstrual Pain In Patients With Primary Dysmenorrhea 1988
- CONTRACTION AND RELAXATION OF HUMAN UTERINE AND PLACENTAL SMOOTH MUSCLE 1987
- Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea 1984
- Distribution analysis of intrauterine pressure in nonpregnant dysmenorrheic women 1984
- Aspects of Inhibition of Myometrial Hyperactivity in Primary Dysmenorrhea 1983
- Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea 1983
- Combined effects of diflunisal and nifedipine on uterine contractility in dysmenorrhoeic patients 1982
- EFFECT OF AN ORAL CONTRACEPTIVE ON UTERINE TONICITY IN WOMEN WITH PRIMARY DYSMENORRHEA 1981
- Prostaglandins in primary dysmenorrhea 1981
- EFFECT OF SALBUTAMOL ON THE NON‐PREGNANT HUMAN UTERUS IN VIVO 1981
- Naproxen sodium, aspirin, and placebo in primary dysmenorrhea 1981
- Anaprox in dysmenorrhea: Reduction of pain and intrauterine pressure 1979
- Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: Effect on prostaglandin levels in menstrual fluid 1979
- Trial of the calcium antagonist nifedipine in the treatment of primary dysmenorrhoea 1979
- Prostaglandins and their Synthesis Inhibitors in Primary Dysmenorrhoea 1979
- ENDOGENOUS PROSTAGLANDINS IN DYSMENORRHEA AND THE EFFECT OF PROSTAGLANDIN SYNTHETASE INHIBITORS (PGSI) ON UTERINE CONTRACTILITY 1979
- INTRODUCTION TO THE SYMPOSIUM “DYSMENORRHEA AND PROSTAGLANDINS” 1979
- NAPROXEN AND NAPROXEN SODIUM IN DYSMENORRHEA: DEVELOPMENT FROM <i>IN VITRO</i> INHIBITION OF PROSTAGLANDIN SYNTHESIS TO SUPPRESSION OF UTERINE CONTRACTIONS IN WOMEN AND DEMONSTRATION OF CLINICAL EFFICACY 1979
- The effect of naproxen-sodium on the prostaglandin concentrations of the menstrual blood and uterine “jet-washings” in dysmenorrehic women 1978
- EFFECTS OF NIFEDIPINE ON MYOMETRIAL ACTIVITY AND LOWER ABDOMINAL PAIN IN WOMEN WITH PRIMARY DYSMENORRHOEA 1978
- The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients 1978
- New concepts in dysmenorrhea 1978
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