The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients

M.O. Pulkkinen, A.I. Csapo
In: Prostaglandins · 1978 · vol. 15(6) , pp. 1055–1062 · doi:10.1016/0090-6980(78)90048-5 · PMID:358295 · W2025441243
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated how ibuprofen affects intrauterine pressure and menstrual pain in patients experiencing dysmenorrhea.

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Abstract

In 12 dysmenorrheic patients we examined the therapeutic action of the Prostaglandin-synthesis inhibitor: Ibuprofen, a non-steroidal analgesic agent. Ibuprofen highly significantly reduced the resting pressure (P less than 0.001), active pressure (P less than 0.001) and frequency (P less than 0.05) of cyclic activity of the uterus, as well as menstrual pain (P less than 0.001). Since these effects occurred after a single oral dose of 800 mg Ibuprofen, without side effects or complications, extensive field trials are recommended with this and other PG-synthesis inhibitors, to assess their therapeutic benefits.

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chemicals 5
ibuprofen prostaglandin ibuprofen ibuprofen ibuprofen

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