Combined effects of diflunisal and nifedipine on uterine contractility in dysmenorrhoeic patients

Axel Forman, K.‐E. Anderson, U. Ulmsten
In: Prostaglandins · 1982 · vol. 23(2) , pp. 237–246 · doi:10.1016/0090-6980(82)90051-x · PMID:6177020 · W2000172350
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This study investigated how diflunisal and nifedipine, alone and in combination, affect uterine contractility in patients experiencing dysmenorrhea.

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Abstract

In eight nulliparous women with severe primary dysmenorrhoea, intrauterine pressure was recorded on the first day of menstruation before and after administration of diflunisal 1000 mg. Uterine activity was significantly decreased in all patients but abolished in none. Seven women experienced almost complete relief of pain. To four of the patients, including the one who did not become pain-free after diflunisal, nifedipine 30 mg was also given. Uterine activity was abolished in all, but the patient not responding to diflunisal had persistent pains. It is suggested that diflunisal may be used for treatment of pain in primary dysmenorrhoea. Addition of nifedipine can produce a further decrease in uterine activity, but whether combined therapy may offer therapeutic advantages remains to be established.

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