Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective

Elke A. Jarboe, E A Jarboe, Jarboe EA, Folkins AK, A K Folkins, Ann K. Folkins, R Drapkin, Ronny Drapkin, Tan A. Ince, T A Ince, Elin S. Agoston, Agoston ES, E S Agoston, Crum CP, C P Crum, Christopher P. Crum
Histopathology · 2008 · vol. 53(2) , pp. 127–138 · doi:10.1111/j.1365-2559.2007.02938.x · PMID:18298580 · W4251987491
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This review proposes two distinct pathways to pelvic epithelial cancer: one originating in ovarian surface epithelium and another from the endosalpinx, highlighting the serous carcinogenic sequence in the distal fallopian tube.

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Abstract

Prolongation of ovarian epithelial cancer survival depends on early detection or improved responses to chemotherapy. Gains in either have been modest at best. Understanding the diverse pathogenesis of this disease is critical to early intervention or prevention. This review addresses six important variables, including (i) cell of origin, (ii) site of origin, (iii) initial genotoxic events, (iv) risks imposed by hereditary and other promoting conditions, (v) subsequent factors that promote different patterns of metastatic spread, and (vi) prospects for intervention. This review proposes two distinct pathways to pelvic epithelial cancer. The first initiates in ovarian surface epithelium (OSE), Mullerian inclusions or endometriosis in the ovary. The second arises from the endosalpinx and encompasses a subset of serous carcinomas. The serous carcinogenic sequence in the distal fallopian tube is described and contrasted with lower grade serous tumors based on tumour location, earliest genetic change and ability (or lack of) to undergo terminal (ciliated) differentiation. Ultimately, a clear understanding of tumour origin and the mechanism(s) leading to the earliest phases of the serous and endometrioid carcinogenic sequences may hold the greatest promise for designing prevention strategies and/or developing new therapies.

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Condition tags

endometriosis

MeSH descriptors

Fallopian Tube Neoplasms Fallopian Tube Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Ovarian Neoplasms Ovarian Neoplasms Pelvic Neoplasms Pelvic Neoplasms Animals Animals Fallopian Tube Neoplasms Fallopian Tube Neoplasms Fallopian Tube Neoplasms Female Female Humans Humans Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (52)

Cited by (4)

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