Genetic Variation of Glutathione S-Transferase M1 Is Associated with Patients with Ovarian Endometriosis and Endometriosis-Related Primary Infertility

Zhang HB, Haibo Zhang, Hai-Bo Zhang, Li Y, Yan Li, Jianlei Wu, Wu JL, Jian-Lei Wu, Zhao J, Jian Zhao, Tian YJ, Yun-Jie Tian, Yunjie Tian, Shan Kang, Kang S
Public health genomics · 2021 · vol. 24(5-6) , pp. 261–266 · doi:10.1159/000517266 · PMID:34384077 · W3187777626
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The GSTM1 null genotype was associated with increased risk of ovarian endometriosis and endometriosis-related primary infertility in northern Chinese women, with lower mRNA expression in affected endometrial tissue.

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Abstract

BACKGROUND: The aim of the study was to investigate the role of the genetic variation of glutathione S-transferase M1 (GSTM1) in the development of ovarian endometriosis and endometriosis-related primary infertility risk. METHODS: This case-control study included 564 women with ovarian endometriosis and 576 normal women in the control group in northern China. The polymorphism of GSTM1 was genotyped by polymerase chain reaction (PCR)/ligase detection reaction method. To assess the biological significance of polymorphisms, the level of GSTM1 mRNA expression in patients' endometrial tissues with different genotypes was detected by quantitative real-time PCR (qRT-PCR). RESULTS: Compared with the positive genotype, the null genotype of GSTM1 was associated with the risk of developing ovarian endometriosis (OR = 1.29, 95% CI = 1.02-1.62). Further analysis showed that patients with a null genotype also had a significantly higher risk of primary infertility than patients with positive genotypes (OR = 1.59, 95% CI = 1.01-2.49). In addition, we found that GSTM1 mRNA expression was present in the endometrial tissue of all patients, but the expression level of patients with a positive genotype was nearly 10 times higher than that of patients with a negative genotype. CONCLUSION: Our results suggest that the GSTM1 polymorphism is not only related to the genetic susceptibility to ovarian endometriosis but also a potential molecular marker of primary infertility in patients with ovarian endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Case-Control Studies Case-Control Studies Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype Glutathione Transferase Glutathione Transferase Glutathione Transferase Humans Humans Infertility, Female Infertility, Female Polymorphism, Genetic Polymorphism, Genetic

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