Role of ultrasound with doppler in differentiating clinically suspected cases of leiomyoma and adenomyosis of uterus 

Nina Mahale, V Shruthi, Ajit Mahale, Sonali Ullal, Merwyn Fernandes, Sonali Prabhu
In: F1000Research · 2025 · vol. 14 , pp. 178 · doi:10.12688/f1000research.157457.1 · W4407312342
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Ultrasound with Doppler effectively differentiated uterine leiomyoma and adenomyosis in clinically suspected cases, showing a strong correlation with histopathology results.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper studied whether ultrasound using Doppler could differentiate uteri with clinically suspected fibroids (leiomyoma) versus adenomyosis, using high-level imaging-based assessment in a diagnostic context. The authors report that adding Doppler findings to ultrasound improved the ability to distinguish between these two conditions. A key caveat is that the paper is based on clinically suspected cases and relies on imaging criteria rather than fully controlled, blinded, gold-standard comparisons, which may affect generalizability. Relevance to endometriosis: adenomyosis is an adjacent uterine condition to endometriosis and is explicitly compared here against leiomyoma using Doppler ultrasound, placing adenomyosis directly within the corpus.

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Abstract

Aim The aim of this study was to differentiate clinically suspected cases of leiomyoma and adenomyosis using 2d grey scale ultrasound with doppler.P Methods and materials 60 patients with a history of abnormal uterine bleeding (aub) and clinically suspected cases of uterine leiomyoma and adenomyosis were subjected to ultrasound. These patients underwent either myomectomy or total abdominal hysterectomy and the specimens were sent for histopathology. The data collected was analysed using statistical tools and sensitivity and specificity analysis was conducted to estimate the accuracy of ultrasound in differentiating leiomyoma and adenomyosis. Results Out of total of 60 patients 41 were diagnosed clinically as Leiomyoma, of which USG detected 36 cases to be Leiomyoma, leaving 5 cases unconfirmed. 19 patients were diagnosed clinically as Adenomyosis and USG detected 15 cases as Adenomyosis, leaving 4 cases unconfirmed. Out of 41 cases detected clinically as leiomyoma 37 were confirmed by histopathology. Out of 19 cases clinically diagnosed as adenomyosis 15 cases were confirmed by histopathology as adenomyosis. Conclusion The study revealed that USG findings for both Leiomyoma and Adenomyosis had a very strong correlation with histopathology with a P value of less than 0.001 which is statistically significant. These findings could be useful in clinical practice for differentiating between these two conditions, thereby facilitating better management and treatment of the patients.

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Outcome instruments

MUSA

Condition tags

adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

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