Clinicopathological spectrum of uterine leiomyomas in a state of Northern India: a hospital based study

Mega Lahori, Aneeta Singh Malhotra, Sakul Sakul, Arvind Khajuria, KC Goswami
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2016 · pp. 2295–2299 · doi:10.18203/2320-1770.ijrcog20162114 · W2469861999
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This hospital-based study analyzed 79 uterine leiomyoma cases in northern India, finding the most common symptoms were menorrhagia, intramural location, and single tumors, with degenerative changes and cellular variants observed.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This hospital-based pathology study from ASCOMS Hospital Jammu analyzed hysterectomy and myomectomy specimens received over one year, including 79 cases of uterine leiomyoma, using gross and microscopic examination to characterize clinicopathological features, secondary changes, and histologic variants. Patients ranged from 18–62 years, with the largest proportion aged 41–50 years, and menorrhagia was reported as the most common symptom (37.97%); fibroid uterus was the most frequent clinical diagnosis (44%). Histologically, intramural leiomyoma was most common (57.43%), most tumors were single (56.96%), and degenerative changes were present in 16.46% with hyaline change the most frequent (6.33%); nine leiomyoma variants were identified, with cellular leiomyoma most common (6.33%). Adenomyosis was associated with leiomyoma in 19.23% of cases, and the main limitation is that the dataset reflects a one-year, hospital specimen series rather than a population-based cohort. Relevance to endometriosis: the paper does not explicitly discuss endometriosis; it was included in the corpus via a keyword match to women’s genital tract pathology.

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Abstract

Background: Myometrial lesions form a diverse group amongst which leiomyoma is the commonest visceral neoplasm affecting females in the reproductive age group. They are noted clinically in 20-30% of women over 30 years of age; are rare prior to the menarche, common in reproductive life and have a tendency to regress after the menopause. Their gross appearances are often altered by various secondary changes. Subtypes of leiomyoma are chiefly of interest as they may mimic malignancy in some cases.Methods: All the hysterectomy and myomectomy specimens which were received in the department of pathology, ASCOMS hospital Jammu, Jammu and Kashmir over a period of one year, out of which 79 cases with leiomyomas were included in the study. The specimens were properly labeled, fixed (in NBF), examined grossly, processed, stained and examined microscopically.Results: Age range of the patients with leiomyoma was18-62 years. Majority of the patients were between 41-50 years (46.84% cases). Menorrhagia was the commonest symptom constituting 37.97% cases and fibroid uterus was the most common clinical diagnosis provided (44%). Most common location of leiomyoma’s was intramural (57.43%) followed by subserosal (30.69%). 56.96% leiomyoma’s were single and 43.04% were multiple. Degenerative changes were observed in 16.46% cases, amongst which hyaline change was the most common (6.33%). 9 types of leiomyoma variants were seen, amongst which cellular leiomyoma (6.33%) was the commonest. Adenomyosis was associated with leiomyoma in 19.23% cases.Conclusions: This study was conducted to analyze the clinic pathologic spectrum of uterine leiomyoma’s in northern India with regards to their clinical presentation, associated changes and variants, and to compare our findings with similar studies from different parts of the world.
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Background

Myometrial lesions form a diverse group amongst which leiomyoma is the commonest visceral neoplasm affecting females in the reproductive age group. They are noted clinically in 20-30% of women over 30 years of age; are rare prior to the menarche, common in reproductive life and have a tendency to regress after the menopause. Their gross appearances are often altered by various secondary changes. Subtypes of leiomyoma are chiefly of interest as they may mimic malignancy in some cases.

Methods

All the hysterectomy and myomectomy specimens which were received in the department of pathology, ASCOMS hospital Jammu, Jammu and Kashmir over a period of one year, out of which 79 cases with leiomyomas were included in the study. The specimens were properly labeled, fixed (in NBF), examined grossly, processed, stained and examined microscopically.

Results

Age range of the patients with leiomyoma was18-62 years. Majority of the patients were between 41-50 years (46.84% cases). Menorrhagia was the commonest symptom constituting 37.97% cases and fibroid uterus was the most common clinical diagnosis provided (44%). Most common location of leiomyoma’s was intramural (57.43%) followed by subserosal (30.69%). 56.96% leiomyoma’s were single and 43.04% were multiple. Degenerative changes were observed in 16.46% cases, amongst which hyaline change was the most common (6.33%). 9 types of leiomyoma variants were seen, amongst which cellular leiomyoma (6.33%) was the commonest. Adenomyosis was associated with leiomyoma in 19.23% cases.

Conclusions

This study was conducted to analyze the clinic pathologic spectrum of uterine leiomyoma’s in northern India with regards to their clinical presentation, associated changes and variants, and to compare our findings with similar studies from different parts of the world. Metrics

References

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