Endometriosis

E J Thomas, Eric J. Thomas, Thomas EJ
BMJ (Clinical research ed.) · 1993 · vol. 306(6871) , pp. 158–159 · doi:10.1136/bmj.306.6871.158 · PMID:8443475 · PMC1676597 · W4242782647
Other OA: bronze CC0 ⤵ 18 in-corpus citations
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This paper discusses strategies, like adding an antidote or developing safer derivatives, to prevent deaths from paracetamol overdose, noting current combinations are costly and underutilized.

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Abstract

encourage more people to take an overdose.It should, however, reduce the likelihood of an accidental overdose being taken from severe pain and increase the chance that if a patient's family knows of the overdose they will encourage him or her to seek prompt medical advice.The pharmaceutical industry is in a pivotal position to address the problem of the continuing high mortality from paracetamol overdose as the addition of an antidote, such as methionine, to all available preparations might prevent every death that currently occurs.At present paracetamol- methionine combinations are costly, little publicised, and rarely prescribed.Adding methionine to all preparations of paracetamol might increase prices and therefore reduce sales.Another solution might be to develop non-hepatotoxic derivatives of paracetamol.It will indeed be tragic if the mortality from paracetamol overdose over the next quarter of a century proves to be as high as that of the last.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Pelvic Neoplasms Endometriosis Endometriosis Female Female Humans Humans Pelvic Neoplasms Pelvic Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

Cited by (18)

Source provenance

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License: CC0 · commercial use OK