Desogestrel versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation

Antonio Simone Laganà, Vittorio Palmara, Roberta Granese, Leonarda Ciancimino, Benito Chiofalo, Onofrio Triolo
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(11) , pp. 794–797 · doi:10.3109/09513590.2014.929658 · PMID:24919887 · W2058884822
RCT OA: closed CC0 ⤵ 6 in-corpus citations
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Desogestrel significantly reduced operative time, infusion volume, and bleeding during hysteroscopic surgery compared to danazol, while also inducing greater endometrial atrophy and fewer side effects.

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Abstract

The aim of this single-center, prospective, randomized, parallel-group study was to compare desogestrel and danazol as preoperative endometrial preparation for hysteroscopic surgery. We enrolled 200 consecutive eligible patients, in reproductive age, with endouterine diseases. Pre- and post-treatment characterization of endometrium was performed by hysteroscopic visual observation and histologic confirmation. The enrolled patients were randomly assigned to two groups: 100 were treated with 75 μg of desogestrel/die, 100 with 100 mg of danazol/die, both orally for 5 weeks, starting on Day 1 of menstruation. We recorded intraoperative data (cervical dilatation time, operative time, infusion volume and severity of bleeding) and drugs' side effects. Post-treatment comparison of endometrial patterns showed a significant more marked effect of desogestrel, respect to danazol, in atrophying endometrium ("normotrophic non-responders" versus "hypotrophic"-"atrophic", p = 0.031). Intraoperative data showed no significant differences between the two groups for cervical dilatation time (p = 0.160), while in the desogestrel group we found a significant reduction of operative time (p = 0.020), infusion volume (p = 0.012), and severity of bleeding (p = 0.004). Moreover, desogestrel caused less side effects (p = 0.031). According to our data analysis, desogestrel showed most marked effect in inducing endometrial atrophy, allowed a better intraoperative management and caused less side effects during treatment.

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Condition tags

die_deep_infiltrating

MeSH descriptors

Blood Loss, Surgical Danazol Desogestrel Estrogen Antagonists Hysteroscopy Progestins Uterine Diseases Adult Blood Loss, Surgical Danazol Danazol Desogestrel Desogestrel Endometrium Endometrium Endometrium Estrogen Antagonists Estrogen Antagonists Female Humans

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References (27)

Cited by (6)

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