The effects of danazol after endometrial resection--results of a randomized, placebo-controlled, double-blind study

M M Erian, Mark Erian, Ignatius Thomas, I L Thomas, R J Buck, Rosemary Buck, M W Lewin, Michaela Lewin, M. Coglan, D Battistutta, Diana Battistutta
The Australian & New Zealand journal of obstetrics & gynaecology · 1998 · vol. 38(2) , pp. 210–214 · doi:10.1111/j.1479-828x.1998.tb03005.x · PMID:9653864 · W2012267297
RCT OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This randomized trial found that high-dose danazol (600 mg daily) significantly increased amenorrhea rates in women after endometrial resection compared to placebo.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We report the results of a controlled, randomized, prospective, 'double blind' evaluation of the effect of danazol treatment in 120 patients after hysteroscopic endometrial resection. After endometrial resection, the women were allocated to 1 of 3 groups: Group A- placebo; Group B - high-dose danazol (600 mg daily); Group C - low-dose danazol (200 mg daily) plus placebo tablets. Tablets were specifically manufactured for the study, were identical in appearance, and were supplied in individual prepackaged boxes. The duration of treatment was 3 months and patients' compliance was noted. Amenorrhoea, dysmenorrhoea and premenstrual tension symptoms were assessed for each group by 1 or 2 independent gynaecologists at follow-up intervals of 6 weeks, 3, 6 and 12 months. A statistically-significant increased rate of amenorrhoea was found in patients who received treatment with the higher-dose danazol (600 mg day) following endometrial resection. While not statistically significant, the same trend was noted with the low-dose danazol. This result should influence our clinical management of women with menorrhagia, and the long-term results on the same cohort of patients are awaited with interest.

My notes (saved in your browser only)

Condition tags

dysmenorrhea

MeSH descriptors

Danazol Endometrium Estrogen Antagonists Menorrhagia Adult Amenorrhea Amenorrhea Combined Modality Therapy Danazol Dose-Response Relationship, Drug Double-Blind Method Endometrium Endoscopy Estrogen Antagonists Female Humans Hysteroscopy Menorrhagia Middle Aged Postoperative Complications

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (4)

References (11)

Cited by (4)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T22:00:41.816812+00:00
License: CC0 · commercial use OK