Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case-control study using a health insurance claims database

Erika Yoshii, Yoshii E, Hayato Yamana, Sachiko Ono, Hiroki Matsui, Matsui H, Hideo Yasunaga, Yasunaga H
American journal of reproductive immunology (New York, N.Y. : 1989) · 2021 · vol. 86(5) , pp. e13486 · doi:10.1111/aji.13486 · PMID:34322942 · W3186388135
Observational OA: closed CC0 ⤵ 17 in-corpus citations
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This study found that allergic diseases, particularly allergic rhinitis, urticaria, and allergic conjunctivitis, along with rheumatoid arthritis, were associated with an increased incidence of endometriosis.

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Abstract

PROBLEM: Immune responses were reported to be associated with the pathogenesis of endometriosis. However, previous studies of an association between allergic or autoimmune diseases and endometriosis have reported inconsistent results. We investigated the association between allergic or autoimmune diseases and the incidence of endometriosis. METHOD OF STUDY: Using a large-scale health insurance claims database in Japan, we identified patients with endometriosis diagnosed between April 2011 and August 2018. For each case, we identified up to four controls with the same age and registration month. Conditional logistic regression analyses were conducted to evaluate the incidence rate ratio (IRR) of endometriosis in women with allergic diseases (asthma, allergic rhinitis, urticaria, atopic dermatitis, allergic conjunctivitis, and type 1 allergies combined), systemic lupus erythematosus, and rheumatoid arthritis compared with women without these diseases. RESULTS: We identified 30 516 cases with endometriosis and 120 976 control participants. Mean age at registration was 30 years. There were significant positive associations between type 1 allergy and endometriosis (IRR, 1.10; 95% confidence interval, 1.06-1.13) and between rheumatoid arthritis and endometriosis (IRR, 1.31; 95% confidence interval, 1.05-1.64). Diagnosis of systemic lupus erythematosus was not associated with increased incidence of endometriosis. Among the different allergic diseases, allergic rhinitis, urticaria, and allergic conjunctivitis were associated with the increased incidence. CONCLUSION: Several allergic diseases were associated with an increased incidence of endometriosis. A higher incidence was also observed in patients with rheumatoid arthritis. Further studies are warranted to elucidate the influence of immune responses on the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Autoimmune Diseases Endometriosis Hypersensitivity Administrative Claims, Healthcare Administrative Claims, Healthcare Adolescent Adolescent Adult Adult Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Case-Control Studies Case-Control Studies Databases, Factual Databases, Factual Endometriosis Endometriosis Endometriosis Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (53)

Cited by (17)

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