Effects of laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy on ovarian reserve, pregnancy, and outcome recurrence

Xin-Hua Yang, Xinhua Yang, Fei Ji, Aixingzi Aili, HaNiKeZi. TuerXun, HaNiKeXi TuerXun, Yan He, Yan Ding
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(3) , pp. 272–275 · doi:10.12891/ceog16062014 · PMID:24992774 · W106943506
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy improved pregnancy rates, reduced recurrence, and had a lesser impact on ovarian reserve compared to cystectomy alone.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This prospective control study compared 63 patients receiving laparoscopic bilateral ovarian endometriosis cystectomy followed by three months of postoperative GnRH-a therapy with 62 patients undergoing laparoscopic bilateral ovarian endometriosis cystectomy alone. Ovarian reserve markers (FSH and FSH/LH, and E2) were measured preoperatively and at postoperative three months or during menstrual days 2–3, and natural pregnancy and cyst recurrence were assessed with 18-month follow-up. After six months, returned FSH within the normal range was higher in the GnRH-a group (95.3% vs 82.2%), and in preoperative infertility patients the natural pregnancy rate (57.1% vs 36.8%) and recurrence rate (12.7% vs 27.4%) differed significantly between groups (p<0.05). This paper is centrally about endometriosis — it evaluates how adding GnRH-a after laparoscopic ovarian endometriosis cystectomy affects ovarian reserve, pregnancy, and recurrence.

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Abstract

OBJECTIVE: The aim of this study was to investigate the impacts of laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy on ovarian reserve, pregnancy outcome and recurrence. MATERIALS AND METHODS: This was a prospective control study. The experimental group: 63 patients with combinations of laparoscopic bilateral ovarian endometrial cystectomies and gonadotropin-releasing hormone agonist (GnRH-a) treatment for three months. CONTROL GROUP: 62 patients with laparoscopic bilateral ovarian endometrial cystectomies. Benchmarks: the changes of follicle stimulating hormone (FSH) and FSH/luteinizing hormone (LH), etradiol (E2) in preoperative and postoperative three months or menstrual two to three days, menstrual two to three days after surgery, natural pregnancy, and cyst recurrence in 18th month during postoperative follow-up. RESULTS: In experimental group after six months, the percentage of returned FSH accounted for 95.3% of normal range, in the control group it was 82.2%, and the difference was significant (p < 0.05). The natural pregnancy rate of preoperative infertility patients (57.1%) was higher than the control (36.8%) (p < 0.05). The recurrence rate of preoperative infertility patients (12.7%) was lower than the control (27.4%) (p < 0.05). CONCLUSION: After bilateral laparoscopic ovarian endometrial cystectomy, an implement of GnRH-a therapy can improve the postoperative pregnancy rate, which changes with clinical stage and patient age, reduces ovarian recurrence, and its influence on ovarian reserve is lesser.
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Abstract

Objective: The aim of this study was to investigate the impacts of laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy on ovarian reserve, pregnancy outcome and recurrence. Materials and Methods: This was a prospective control study. The experimental group: 63 patients with combinations of laparoscopic bilateral ovarian endometrial cystectomies and gonadotropin-releasing hormone agonist (GnRH-a) treatment for three months. Control group: 62 patients with laparoscopic bilateral ovarian endometrial cystectomies. Benchmarks: the changes of follicle stimulating hormone (FSH) and FSH / luteinizing hormone (LH), etradiol (E2) in preoperative and postoperative three months or menstrual two to three days, menstrual two to three days after surgery, natural pregnancy, and cyst recurrence in 18th month during postoperative follow-up. Results: In experimental group after six months, the percentage of returned FSH accounted for 95.3% of normal range, in the control group it was 82.2%, and the difference was significant (p < 0.05). The natural pregnancy rate of preoperative infertility patients (57.1%) was higher than the control (36.8%) (p < 0.05). The recurrence rate of preoperative infertility patients (12.7%) was lower than the control (27.4%) (p < 0.05). Conclusion: After bilateral laparoscopic ovarian endometrial cystectomy, an implement of GnRH-a therapy can improve the postoperative pregnancy rate, which changes with clinical stage and patient age, reduces ovarian recurrence, and its influence on ovarian reserve is lesser.

Keywords

- Laparoscopic ovarian endometrial cystectomy - Ovarian reserve - Sex hormone - Pregnancy outcomes - Recurrence

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Ovarian Cysts Chemotherapy, Adjuvant Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Humans Infertility, Female Infertility, Female Infertility, Female Laparoscopy Luteinizing Hormone Luteinizing Hormone

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