Clinical and anamnestic features of women with genital endometriosis depending on the presence or absence of infertility

T. A. Ponomareva, O. B. Altukhova, Irina Ponomarenko, Yu. V. Kolesnikov, Mikhail Churnosov
In: Meditsinskiy sovet = Medical Council · 2025 · pp. 126–135 · doi:10.21518/ms2025-139 · W4410172964
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study analyzed clinical and anamnestic features of 395 women with genital endometriosis, finding that those with infertility more frequently presented with early reproductive age, lower body weight, acute pelvic pain, earlier sexual debut, and a history of STDs and ovarian surgeries.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The study analyzed 395 women with morphologically confirmed genital endometriosis after surgery, comparing 132 with concomitant infertility versus 263 without infertility, using detailed medical and anamnestic data. Women in the infertility group more often were early reproductive age (20–35 years) and had lower body mass, and they reported higher frequencies of acute pelvic pain, premenstrual syndrome, and constipation; they also had earlier sexual debut, more frequent prior abortion (including earlier timing of induced abortions), and more frequent sexually transmitted infections, along with higher rates of ovarian surgery and ectopic pregnancies. The paper explicitly notes that there are no direct proofs of endometriosis causing infertility, framing the observed differences as clinically relevant characteristics rather than definitive causality. This paper is centrally about endometriosis — it compares genital endometriosis patients with versus without infertility and characterizes associated clinical and anamnestic features.

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Abstract

Introduction. Genital endometriosis makes the “top three” gynecologic disorders and is of high social significance. According to various authors, from 30 to 50% of patients with endometriosis suffer from infertility. As of today, there are many theories describing the occurrence of endometriosis-associated infertility, however, there is no direct evidence of infertility due to endometriosis. Aim. To carry out a detailed analysis of the medical-biological and clinical-anamnestic features of patients with genital endometriosis depending on the presence or absence of infertility. Materials and methods. This study included 395 patients with genital endometriosis (132 women with genital endometriosis and concomitant infertility, 263 – with genital endometriosis without infertility). The diagnosis of genital endometriosis was established based on the results of morphological examination after surgical treatment. Results. It was found that among women with genital endometriosis and infertility the patients of early reproductive age (from 20 to 35 years old, 56.06%) with body weight deficiency prevailed. This group was characterized by a higher incidence of acute pelvic pain (1.9 times), premenstrual syndrome (1.8 times), constipation (1.3 times), earlier sexual debut (14 to 18 years). A single abortion was more often recorded; an earlier age of artificially performed abortions – from 20 to 30 years, was revealed; sexually transmitted diseases (STDs) were registered more often (2.7 times) than in the group without infertility. Surgical interventions on ovaries in the group of individuals with genital endometriosis and infertility were 3.2 times more frequent, ectopic pregnancies – 4 times more frequent. Conclusion. The conducted study allowed revealing significant differences in the biomedical and clinical-anamnestic characteristics of patients with genital endometriosis and concomitant infertility and without infertility, which should be taken into account in the clinical management of patients.

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endometriosisinfertility

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