MOLECULAR-GENETIC DETERMINANTS OF INFERTILITY IN GENITAL ENDOMETRYOSIS

Viktor E. Radzinsky, Oksana B. Altuchova
In: Research Result Medicine and Pharmacy · 2018 · vol. 4(3) , pp. 28–37 · doi:10.18413/2313-8955-2018-4-3-0-3 · W2994485315
article OA: diamond CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the molecular-genetic factors influencing infertility in individuals with genital endometriosis by analyzing gene expression profiles and identifying differentially expressed genes.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study evaluated associations between genetic polymorphisms of candidate genes and infertility in 428 women with genital endometriosis, comparing 132 patients with endometriosis-associated infertility to 296 with achieved pregnancy after assessment. Genotyping was performed for 32 polymorphic loci, and combinations of variants were analyzed using APSampler. Multiple variant combinations involving MMP2, MMP3, MMP7, MMP9, IL-8, RANTES, ITGA C, SDF1, and related loci were reported as risk factors for infertility, while combinations involving PGR, ESR1, TYMS, and MTRR were reported as protective factors, with reported odds ratios and permutation-adjusted p-values. The authors’ main limitation, implied by the approach, is that only predefined candidate gene polymorphisms were assessed rather than genome-wide variation. This paper is centrally about endometriosis — it investigates molecular-genetic determinants of infertility specifically in genital endometriosis.

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infertility

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