T. A. Ponomareva

One of the gynecological diseases with high social, medical, and economic significance is endometriosis. Among women of reproductive age, the prevalence of this disease reaches 10% and, according to various authors, varies from 2% to 27%. O…

Objective. The study of the involvement of GWAS-significant (GWAS — Genome-Wide Association Study) is a genome—wide study of the links between single-nucleotide polymorphisms and human diseases; a method for identifying genetic variants ass…

Introduction. Genital endometriosis makes the “top three” gynecologic disorders and is of high social significance. According to various authors, from 30 to 50% of patients with endometriosis suffer from infertility. As of today, there are …

Endometriosis is a hormone-dependent disease, in the pathophysiology of which sex hormones (androgens, estrogens, etc.) are involved. The level of bioactive androgens/estrogens (in the free state) in the organism largely depends on sex horm…

In this study, we examine the associations of nine polymorphic loci associated with the level of sex hormone binding globulin (SHBG) with the development of infertility in women with genital endometriosis. The study was conducted on a sampl…

Introduction. The results of a number of studies indicate the comorbidity of endometriosis with various diseases, such as uterine fibroids, endometrial cancer, migraine, depression, infertility, bronchial asthma, and stomach diseases. Aim. …

Here, we analyze the data on genetic factors involved in developing endometriosis available in current publications. To date, the genome-wide associative studies (GWAS) have revealed more than 190 loci associated with endometriosis developm…