Mikhail Churnosov

The work was performed to assess the relationship of single-nucleotide polymorphisms (SNPs), which determine the concentration of sex hormones (confirmed in previously performed genome-wide studies (GWASs)), with the risk of endometrial hyp…

Objective. The study of the involvement of GWAS-significant (GWAS — Genome-Wide Association Study) is a genome—wide study of the links between single-nucleotide polymorphisms and human diseases; a method for identifying genetic variants ass…

Introduction. Genital endometriosis makes the “top three” gynecologic disorders and is of high social significance. According to various authors, from 30 to 50% of patients with endometriosis suffer from infertility. As of today, there are …

Endometriosis is a hormone-dependent disease, in the pathophysiology of which sex hormones (androgens, estrogens, etc.) are involved. The level of bioactive androgens/estrogens (in the free state) in the organism largely depends on sex horm…

In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 w…

The main goal of this study was to consider the role of obesity/overweight as a potential modifier of associations between gene single nucleotide polymorphisms (SNPs) affecting the sex hormone-binding globulin level (SHBGlevel) and uterine …

In this study, we examine the associations of nine polymorphic loci associated with the level of sex hormone binding globulin (SHBG) with the development of infertility in women with genital endometriosis. The study was conducted on a sampl…

Introduction. The results of a number of studies indicate the comorbidity of endometriosis with various diseases, such as uterine fibroids, endometrial cancer, migraine, depression, infertility, bronchial asthma, and stomach diseases. Aim. …

We aimed to explore the potential link of maternal age at menarche (mAAM) gene polymorphisms with risk of the fetal growth restriction (FGR). This case (FGR)-control (FGR free) study included 904 women (273 FGR and 631 control) in the third…

Эндометриоз является мультифакториальным заболеванием, что подтверждается в ходе многочисленных исследований. Появление эндометриоза является результатом воздействия анатомических, гормональных, иммунологических, экологических и генетически…

Introduction. Endometriosis is a common gynecological disease that has important socio-economic significance for both sick women, their families, and society as a whole. It is often combined with other hyperplastic diseases of the uterus. A…

Studying mechanisms of development and the causes of various human diseases continues to be the focus of attention of various researchers [...].

Introduction. One of the most common clinical manifestations of endometriosis is infertility, in the formation of which genetic factors may be involved. Objective. The aim of the study was to evaluate the role of polymorphic loci of sex hor…

In this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborns. All pregnant women underwe…

Here, we analyze the data on genetic factors involved in developing endometriosis available in current publications. To date, the genome-wide associative studies (GWAS) have revealed more than 190 loci associated with endometriosis developm…

В работе приведены современные данные о генетических факторах развития эндометриоза, полученные в результате полногеномных исследований (genome-wide association study — GWAS). В настоящее время в литературе представлены результаты 15 GWAS-…

The present study was designed to examine whether sex hormone polymorphisms proven by GWAS are associated with endometriosis risk. Unrelated female participants totaling 1376 in number (395 endometriosis patients and 981 controls) were recr…

В статье рассматривается связь между генами хемокинов и внутренним генитальным эндометриозом в сочетании с гиперпластическими процессами эндометрия

В статье представлены современные данные литературы об этиологии, молекулярных механизмах формирования эндометриоза и факторах риска его развития. Согласно современным представлениям, эндометриоз является многофакторным заболеванием, в раз…

Research questionAre the candidate genes for age at menarche associated with a risk of endometriosis?DesignFifty-two candidate single nucleotide polymorphisms (SNP) for age at menarche, their gene-gene and gene-environment interactions were…

Age at menarche (AAM) is an important marker of the pubertal development and function of the hypothalamic-pituitary-ovarian system. It was reported as a possible factor for a risk of uterine leiomyoma (UL). However, while more than 350 loci…

Data on the allele and genotype frequencies of the five single nucleotide polymorphisms (SNPs) 5 genes - rs1514175 TNNI3K, rs713586 RBJ, rs887912 FANCL, rs2241423 MAP2K5, rs12444979 GPRC5B in Russian women are presented. Several genome-wide…