Malignant peritoneal mesothelioma in patients with endometriosis

Kelly J. Butnor, Butnor KJ, Justin Rueckert, Rueckert J, Elizabeth N. Pavlisko, Thomas A Sporn, Sporn TA, Victor L Roggli, Roggli VL
Journal of clinical pathology · 2018 · vol. 71(11) , pp. 971–974 · doi:10.1136/jclinpath-2018-205099 · PMID:29794065 · W2803236549
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This study identified six women with malignant peritoneal mesothelioma and endometriosis, noting a younger median age at diagnosis compared to those without endometriosis, suggesting chronic inflammation may be a factor.

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Abstract

AIMS: Florid mesothelial hyperplasia is known to result from endometriosis. Well-differentiated papillary mesothelioma and multiloculated peritoneal inclusion cysts have also been described in women with endometriosis. To our knowledge, peritoneal diffuse malignant mesothelioma (MM) arising in the setting of endometriosis has not been reported. The purpose of this study is to report the clinicopathological characteristics of women with MM and endometriosis. METHODS: The surgical pathology files of a tertiary academic medical centre and the consultation files of one of the study authors were reviewed for cases of MM in females with and without endometriosis. RESULTS: Six women with MM and endometriosis ranging in age from 29 to 55 years (median=45 years) were identified. All had peritoneal MM and endometriosis involving the peritoneum and/or adnexa. Five had epithelioid MM and one had biphasic MM. Two had paraoccupational exposure to asbestos. The median age of women with MM and endometriosis (44.5 years) was significantly less than the median age of cases without endometriosis (58.0 years) (p value=0.01). CONCLUSIONS: To our knowledge, this is the first report of MM in women with endometriosis. Interestingly, MM in the setting of endometriosis has only been observed in the peritoneum and not in other serosal cavities. The findings in the present study suggest that chronic serosal inflammation secondary to endometriosis may be an inducing factor in rare cases of MM of the peritoneum.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lung Neoplasms Mesothelioma Peritoneal Neoplasms Peritoneum Adult Asbestos Asbestos Biomarkers, Tumor Biomarkers, Tumor Biopsy Endometriosis Endometriosis Environmental Exposure Environmental Exposure Female Humans Lung Neoplasms Lung Neoplasms Lung Neoplasms

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