Endometriosis in a Patient with Mayer-Rokitansky-Küster-Hauser Syndrome and Complete Uterine Agenesis: Evidence to Support the Theory of Coelomic Metaplasia

Mok-Lin EY, Evelyn Mok-Lin, Evelyn Y Mok-Lin, Adam Wolfberg, Wolfberg A, Heidi Hollinquist, Hollinquist H, Laufer MR, Marc R Laufer
Journal of pediatric and adolescent gynecology · 2009 · vol. 23(1) , pp. e35–e37 · doi:10.1016/j.jpag.2009.02.010 · PMID:19589710 · W2166530392
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case report describes endometriosis in a patient with Mayer-Rokitansky-Küster-Hauser syndrome and complete uterine agenesis, providing evidence to support the coelomic metaplasia theory of endometriosis origin.

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Abstract

BackgroundThere are many hypotheses regarding the pathogenesis of endometriosis. Most theories, including retrograde menstruation, require the existence of a uterine structure and endometrial tissue. We report endometriosis with the absence of a uterus. This finding supports the theory of coelomic metaplasia.CaseA 20-year-old with Mayer-Rokitansky-Küster-Hauser syndrome presented with increasing pelvic pain and underwent laparoscopy. Uterine, cervical, vaginal, and tubal agenesis was confirmed. Stage I endometriosis was visualized in the posterior cul-de-sac and destroyed. She received medical therapy for 5 years until she represented with pain and underwent another laparoscopy, at which endometriosis was again identified and destroyed.Summary and conclusionThis case of endometriosis in a patient with complete uterine agenesis supports the theory of coelomic metaplasia.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Uterus Endometriosis Female Humans Metaplasia Mullerian Ducts Mullerian Ducts Mullerian Ducts Syndrome Uterus Young Adult

Citation neighborhood

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Cited by (48)

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