GnRH agonist administration prior to embryo transfer in freeze-all cycles of patients with endometriosis or aberrant endometrial integrin expression

Surrey ES, Eric S. Surrey, Mandy Katz-Jaffe, Katz-Jaffe M, Mandy G. Katz‐Jaffe, Kondapalli LV, Laxmi V. Kondapalli, Robert L Gustofson, R.L. Gustofson, Gustofson RL, William B. Schoolcraft, Schoolcraft WB
Reproductive BioMedicine Online · 2017 · vol. 35(2) , pp. 145–151 · doi:10.1016/j.rbmo.2017.05.004 · PMID:28601378 · W2615276840
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This study investigated the effect of GnRH agonist administration before embryo transfer on outcomes in freeze-all cycles for patients with endometriosis or abnormal endometrial integrin expression.

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Abstract

Prolonged gonadotrophin-releasing hormone agonist (GnRHa) administration before IVF with fresh embryo transfer to patients with endometriosis or aberrant endometrial integrin expression (-integrin) improves outcomes but may suppress ovarian response and prevents elective cryopreservation of all embryos. This retrospective cohort pilot study evaluates freeze-all cycles with subsequent prolonged GnRHa before embryo transfer in these populations. Patients from 2010 to 2015 who met inclusion criteria and received a long-acting GnRHa every 28 days twice before FET were evaluated. A subset underwent comprehensive chromosomal screening (CCS) after trophectoderm biopsy. Three groups were identified: Group 1: + CCS, +endometriosis (20 patients, 20 transfers); Group 2: +CCS, -integrin (12 patients, 13 transfers); Group 3: no CCS, +endometriosis or -integrin (10 patients, 12 transfers); Group 4: all transfers after CCS for descriptive comparison only (n = 2809). Baseline characteristics were similar among Groups 1-3 except that the mean surgery to oocyte aspiration interval was longer for Group 1 than Group 3. Implantation and ongoing pregnancy rates were statistically similar among the three groups and compared favourably to Group 4. A non-significant trend towards improved outcomes was noted in Group 1. Prolonged GnRHa after freeze-all in these patients avoids excessive ovarian suppression and results in excellent outcomes.

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Condition tags

endometriosis

MeSH descriptors

Embryo Transfer Embryo Transfer Endometriosis Endometrium Fertilization in Vitro Freezing Freezing Gonadotropin-Releasing Hormone Integrin beta3 Leuprolide Adult Adult Endometriosis Endometriosis Endometrium Endometrium Female Female Fertilization in Vitro Fertilization in Vitro

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