PATHOGENETIC ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR (CSF-1) IN PREDICTING ENDOMETRIOID DISEASE

Yuliia A Orlova, Yu. A. Orlova, Orlova YA, A. М. Hromova, Hromova AM, Antonina M Hromova, Ігор Петрович Кайдашев, Igor P Kaidashev, Kaidashev IP, O. A. Shlykova, Shlykova OA, Oksana A Shlykova, O. V. Izmailova, Olha V Izmailova, Vitaliiy B. Martynenko, Martynenko VB
Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2021 · vol. 74(8) , pp. 1939–1944 · doi:10.36740/wlek202108128 · PMID:34537747 · W3201166379
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Macrophage colony-stimulating factor (CSF-1) levels are significantly elevated in the peritoneal fluid and menstrual blood of women with endometrioid disease, suggesting its diagnostic and prognostic utility.

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Abstract

OBJECTIVE: The aim: To assess the CSF - 1 level in peritoneal fluid and menstrual blood of women with endometrioid disease and to investigate its diagnostic and prognostic specificity. PATIENTS AND METHODS: Materials and methods: The study included 80 women of child-bearing age (mean age 30.95 ± 6.49 years) with benign gynaecological pathology of the ovaries and / or fallopian tubes. The women included in the study were divided into two groups: study group (n = 50, mean age 31.04 ± 6.3 years), consisting of patients with confirmed endometrioid disease, and control group (n = 30, mean age 30.8 ± 6.8 years), involving individuals without signs of endometriosis (p> 0.05). RESULTS: Results: We have found significantly higher level of CSF-1 content in the peritoneal fluid in the subjects of the study group (2027.05 ± 732.64 pg / ml) compared with those in the control group (1725.62 ± 466.06 pg / ml) (p = 0.029). There is a tendency towards an increase in CSF-1 level in women with endometriosis in its more severe stages and more severe and extended adhesions. The investigation of CSF-1 content in menstrual blood has demonstrated significant increase in its values in the women of the study group (9431.6 ± 2866.22 pg / ml) compared with the values in the control group (6637.12 ± 954.05 pg / ml), (p = 0.00004). Thus, there is a tendency towards the growth in CSF-1 level in peritoneal fluid and menstrual blood in women with endometriosis and concurrent increase in severity of the disease. CONCLUSION: Conclusions: There has been found significant increase in CSF-1 content in women with endometrioid disease in both peritoneal fluid and menstrual blood (1.2 and 1.4 times, respectively). Thus, macrophage growth factor (CSF-1) can be used as a diagnostic and prognostic criterion in evaluating the progression of endomertioid disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Uterine Diseases Uterine Diseases Adult Adult Ascitic Fluid Ascitic Fluid Female Female Humans Humans Macrophage Colony-Stimulating Factor Macrophage Colony-Stimulating Factor Tissue Adhesions Tissue Adhesions Young Adult Young Adult

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