Genetic contribution of the interferon gamma dinucleotide-repeat polymorphism in South Indian women with endometriosis

Roya Rozati, Rozati R, Vanaja MC, Maria Celestina Vanaja, Nasaruddin Khaja, Nasaruddin K, Khaja Nasaruddin
Journal of Obstetrics and Gynaecology Research · 2010 · vol. 36(4) , pp. 825–831 · doi:10.1111/j.1447-0756.2010.01201.x · PMID:20666952 · W1504429886
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This study found that the interferon-gamma (IFNG) gene CA-repeat polymorphism is associated with endometriosis susceptibility in South Indian women, with increased frequencies of the a12 allele and genotype in patients.

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Abstract

AIM: To investigate whether the interferon-gamma (IFNG) gene dinucleotide (CA)-repeat polymorphism is responsible in part for genetic susceptibility to endometriosis in South Indian women. METHODS: Following extraction of genomic DNA, genotyping of interferon-gamma CA-repeat polymorphism was performed using genescan technology. RESULTS: The global IFNG allele frequencies in all patients with endometriosis were significantly different from those in the control women (chi(2) = 37.062; 6 degrees of freedom; P < or = 0.0001). Significant difference was observed in global allele frequencies between the control women and each clinical subgroup of patients with endometriosis except for patients suffering from endometriosis associated with adenomyosis. The difference was due to an increase in a12 (112 bp) allele in the patients with endometriosis and each clinical subgroup of patients with endometriosis. The distribution of the IFNG a12 genotypes was significantly different between patients with endometriosis and the control women. (chi(2) = 10.635; 2 degrees of freedom; P = 0.0049). A significant difference in the IFNG a12 genotypes was found only among the three clinical subgroups. CONCLUSION: These results suggest that the IFNG gene CA-repeat polymorphism is associated with susceptibility to endometriosis in South Indian women.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Dinucleotide Repeats Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Interferon-gamma Alleles Alleles Case-Control Studies Case-Control Studies Chi-Square Distribution Chi-Square Distribution Dinucleotide Repeats Dinucleotide Repeats Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genotype

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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